Large Noncoding RNAs Are Promising Regulators in Embryonic Stem Cells

Embryonic stem cells （ESCs） hold great promises for treating and studying numerous devastating diseases. The molecular basis of their potential is not completely understood. Large noncoding RNAs （lncRNAs） are an important class of gene regulators that play essential roles in a variety of physiologic...

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Bibliographic Details
Published in:Journal of genetics and genomics 2015-03, Vol.42 (3), p.99-105
Main Authors: Li, Ya-Pu, Wang, Yangming
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Cellular Reprogramming
Differentiation
Embryonic stem cells
Embryonic Stem Cells - cytology
Embryonic Stem Cells - metabolism
ESCs
Gene Expression Regulation
Humans
Induced pluripotent stem cells
Large noncoding RNAs
MicroRNAs - metabolism
RNA, Long Noncoding - classification
RNA, Long Noncoding - metabolism
RNA-Binding Proteins - metabolism
Self-renewal
分子基础
基因调节
多能干细胞
病理过程
胚胎干细胞
自我更新
非编码RNA
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Summary:Embryonic stem cells （ESCs） hold great promises for treating and studying numerous devastating diseases. The molecular basis of their potential is not completely understood. Large noncoding RNAs （lncRNAs） are an important class of gene regulators that play essential roles in a variety of physiologic and pathologic processes. Dozens of lncRNAs are now identified to control ESC self-renewal and differentiation. Research on lncRNAs may provide novel insights into manipulating the cell fate or reprogramming somatic cells into induced pluripotent stem cells （iPSCs）. In this review, we summarize the recent research efforts in identifying functional lncRNAs and understanding how they act in ESCs, and discuss various future directions of this field.
ISSN:1673-8527
DOI:10.1016/j.jgg.2015.02.002