Serum cystatin C and microalbuminuria in burn patients with acute kidney injury

• Published in: European journal of clinical investigation 2015-06, Vol.45 (6), p.594-600
• Main Authors: Yim, Haejun, Kym, Dohern, Seo, Dong Kook, Yoon, Jaechul, Yang, Hyeong-Tae, Lee, Jeonghwan, Cho, Yong-Suk, Hur, Jun, Chun, Wook, Han, Seong-Woo
• Format: Article
• Language: English
• Subjects: Acute kidney injury; Acute Kidney Injury - diagnosis; Acute Kidney Injury - etiology; Albuminuria - blood; Albuminuria - etiology; Biomarkers - metabolism; Burns - blood; Burns - complications; Burns - urine; Creatinine - metabolism; cystatin C; Cystatin C - metabolism; Early Diagnosis; Female; Humans; major burn; Male; microalbuminuria; Middle Aged; Prospective Studies; Statistics as Topic
• ISSN: 0014-2972; 1365-2362
• DOI: 10.1111/eci.12452

Background This study was aimed at evaluating the effectiveness of serum cystatin C and microalbuminuria as diagnostic markers for acute kidney injury (AKI) in major burn patients. Materials and methods Major burn adult patients admitted to the burn intensive care unit within 24 h from the onset of injury were enrolled. Serum cystatin C and microalbuminuria (albumin–creatinine ratio, ACR) were obtained at postburn days 1, 3, 7, 14, 21 and 28. The patients were divided into two groups of the AKI group and the nonacute kidney injury group. Results A total of 97 patients were enrolled in this study. Acute kidney injury was diagnosed in 40 patients (41·2%) at postburn day 17·3 ± 7·9. The area under the curve of the receiver operating characteristic curve for serum cystatin C was 0·808 (95% CI, 0·711–0·905, P