Reduced frontal and occipital lobe asymmetry on the CT-scans of schizophrenic patients. Its specificity and clinical significance

Frontal and occipital lobe width were determined in the computed tomographic (= CT) scans of 135 schizophrenic patients, 158 neuropsychiatrically healthy and 102 psychiatric control subjects, including patients with affective psychosis, neurosis and schizoaffective psychosis. Most healthy right hand...

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Bibliographic Details
Published in:Journal of Neural Transmission 1995-01, Vol.99 (1-3), p.63-77
Main Authors: Falkai, P., Schneider, T., Greve, B., Klieser, E., Bogerts, B.
Format: Article
Language:English
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Summary:Frontal and occipital lobe width were determined in the computed tomographic (= CT) scans of 135 schizophrenic patients, 158 neuropsychiatrically healthy and 102 psychiatric control subjects, including patients with affective psychosis, neurosis and schizoaffective psychosis. Most healthy right handed subjects demonstrate a relative enlargement of the right frontal as well as left occipital lobe compared to the oposite hemisphere. These normal frontal and occipital lobe asymmetries were selectively reduced in schizophrenics (f.: 5%, p < .0005; o.: 3%, p < .05), irrespective of the psychopathological subgroup. Schizophrenic neuroleptic non-responders revealed a significant reduction of frontal lobe asymmetry (3%, p < .05), while no correlation between BPRS-subscores and disturbed cerebral laterality could be detected. In sum the present study demonstrates disturbed cerebral lateralisation in schizophrenic patients supporting the hypothesis of interrupted early brain development in schizophrenia.
ISSN:0300-9564
1435-1463
DOI:10.1007/BF01271470