High-dose Chemotherapy Followed by Autologous and Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Follicular Non-Hodgkin's Lymphoma in the Rituximab Era

High-dose chemotherapy in lymphomas, and mainly non-Hodgkin's lymphomas, has been advancing since the 1970s. This therapeutic strategy is based on the supposed existence of a dose-response curve for cytotoxic agents. However, the available data are contradictory, so high-dose chemotherapy canno...

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Bibliographic Details
Published in:Tumori 2015-01, Vol.101 (1), p.2-7
Main Authors: Escobar, Ignacio García, de Ibargüen, Blanca Cantos Sánchez, de Juan, Virginia Calvo, Alonso, C. Maximiano, García, Miriam Méndez, Ruíz, Antonio Carlos Sánchez, Pulla, Mariano Provencio
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal, Murine-Derived - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Bone Marrow Purging
Clinical Trials as Topic
Drug Administration Schedule
Evidence-Based Medicine
Hematopoietic Stem Cell Transplantation
Humans
Immunologic Factors - therapeutic use
Lymphoma, Follicular - drug therapy
Lymphoma, Follicular - surgery
Lymphoma, Follicular - therapy
Neoadjuvant Therapy - methods
Recurrence
Rituximab
Transplantation, Autologous
Transplantation, Homologous
Treatment Outcome
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Summary:High-dose chemotherapy in lymphomas, and mainly non-Hodgkin's lymphomas, has been advancing since the 1970s. This therapeutic strategy is based on the supposed existence of a dose-response curve for cytotoxic agents. However, the available data are contradictory, so high-dose chemotherapy cannot be guaranteed as consolidation treatment for first-remission follicular lymphoma or diffuse large cell lymphoma. The objective of this paper is to review the current knowledge about high-dose chemotherapy followed by hematopoietic stem cell transplantation in follicular non-Hodgkin's lymphoma. The published studies on follicular lymphoma after first remission, recurrent follicular lymphoma, and transformed follicular lymphoma were assessed together with the data available on diffuse large cell lymphoma. During analysis of the studies, difficulties were encountered in comparing studies due to the heterogeneous nature of the data. High-dose chemotherapy as consolidation treatment after first remission or in recurrent or refractory disease was also analyzed.
ISSN:0300-8916
2038-2529
DOI:10.5301/tj.5000203