Serum total oxidant and antioxidant status in earthquake survivors with post-traumatic stress disorder

Oxidative stress has been shown to play an important role in the pathogenesis of post-traumatic stress disorder (PTSD). Although there are some studies on oxidative stress and PTSD, there is no report available on the serum total oxidant and antioxidant status in earthquake survivors with PTSD. Ther...

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Bibliographic Details
Published in:Acta neuropsychiatrica 2015-06, Vol.27 (3), p.153-158
Main Authors: Ozdemir, Pinar Guzel, Kaplan, İbrahim, Uysal, Cem, Bulut, Mahmut, Atli, Abdullah, Bez, Yasin, Kaya, Mehmet Cemal, Ozdemir, Osman
Format: Article
Language:English
Subjects:
Adult
Antioxidants
Antioxidants - metabolism
Disasters
Earthquakes
Female
Humans
Male
Mental disorders
Original Articles
Oxidants - blood
Oxidative stress
Oxidative Stress - physiology
Post traumatic stress disorder
Spectrophotometry - methods
Stress Disorders, Post-Traumatic - blood
Stress Disorders, Post-Traumatic - etiology
Stress Disorders, Post-Traumatic - psychology
Surveys and Questionnaires
Survivors - psychology
Turkey
Vitamin E
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Summary:Oxidative stress has been shown to play an important role in the pathogenesis of post-traumatic stress disorder (PTSD). Although there are some studies on oxidative stress and PTSD, there is no report available on the serum total oxidant and antioxidant status in earthquake survivors with PTSD. Therefore, this study aimed to investigate the serum total oxidant and antioxidant status in earthquake survivors with chronic PTSD. The study group included 45 earthquake survivors with PTSD and 40 earthquake survivors without PTSD. The oxidative status was determined using the total antioxidant status and total oxidant status (TOS) measurements and by calculating the oxidative stress index (OSI). There were no statistically significant differences in the total antioxidant status, TOS, or OSI when comparing individuals with and without PTSD (all, p>0.05). There were no correlations between Clinician-Administered PTSD Scale scores and oxidant and antioxidant stress markers (all, p>0.05). Our results suggest that the total oxidant and antioxidant status may not affect earthquake survivors with PTSD. This is the first study to evaluate the oxidative status in earthquake survivors with PTSD. Further studies are necessary to confirm these findings.
ISSN:0924-2708
1601-5215
DOI:10.1017/neu.2014.47