Dual Antiplatelet Therapy in Patients with Glucose-6-Phosphate Dehydrogenase Deficiency undergoing PCI with Drug-Eluting Stents

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect, affecting more than 400 million people worldwide. In patients with G6PD deficiency, the use of aspirin is controversial, since past studies have reported a potential risk of haemolysis related to its administ...

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Bibliographic Details
Published in:Journal of atherosclerosis and thrombosis 2015, Vol.22 (5), p.535-541
Main Authors: Biscaglia, Simone, Ferri, Alessandra, Pavasini, Rita, Campo, Gianluca, Ferrari, Roberto
Format: Article
Language:English
Subjects:
Adult
Aged
Drug-Eluting Stents
Female
Glucosephosphate Dehydrogenase Deficiency - drug therapy
Humans
Male
Middle Aged
Platelet Aggregation Inhibitors - therapeutic use
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Summary:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect, affecting more than 400 million people worldwide. In patients with G6PD deficiency, the use of aspirin is controversial, since past studies have reported a potential risk of haemolysis related to its administration, even at low doses. More recent publications have shown that low-dose aspirin administration is safe in these patients. At the same time, no authors have previously reported more than single cases regarding low-dose aspirin treatment in patients with G6PD deficiency undergoing percutaneous coronary intervention (PCI), and most physicians are still sceptical about aspirin administration in these patients. In this paper, we report a case series of five patients with G6PD deficiency receiving PCI with drug-eluting stents (DES) and treatment with dual antiplatelet therapy (DAPT) containing low-dose aspirin, without clinical complications. Moreover, we discuss our internal protocol for managing these patients and provide an overview of the available data.
ISSN:1880-3873
DOI:10.5551/jat.29371