Scanning electron microscopy for flow-diverting stent research: technical tips and tricks

Flow-diverting (FD) stents represent a new concept in the treatment of intracranial aneurysms with challenging anatomical dispositions. Having been introduced to clinical practice only in the last 5 years and featuring complex mechanisms of action, they are still under research. Scanning electron mi...

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Bibliographic Details
Published in:Microscopy 2015-06, Vol.64 (3), p.219-223
Main Authors: Iosif, Christina, Carles, Pierre, Trolliard, Gilles, Yardin, Catherine, Mounayer, Charbel
Format: Article
Language:English
Subjects:
Animals
Carotid Artery, Internal - surgery
Intracranial Aneurysm - surgery
Intracranial Thrombosis - surgery
Microscopy, Electron, Scanning - methods
Pilot Projects
Stents
Swine
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Summary:Flow-diverting (FD) stents represent a new concept in the treatment of intracranial aneurysms with challenging anatomical dispositions. Having been introduced to clinical practice only in the last 5 years and featuring complex mechanisms of action, they are still under research. Scanning electron microscopy, as part of an animal research protocol, provides detailed surface observations of neointimal healing at the aneurysm's neck, as well as covered side branch ostia, allowing for the confirmation of scientific hypotheses and observations. Technical adaptations of preparation protocols are presented based on a pilot study on Large White pigs, stented with FD stents at carotid bifurcations.
ISSN:2050-5698
2050-5701
DOI:10.1093/jmicro/dfv009