Occupational exposure to solvents, metals and welding fumes and risk of Parkinson's disease

Abstract Objectives The aim of this study was to investigate the potential association between occupational exposure to solvents, metals and/or welding fumes and risk of developing Parkinson's disease (PD). Methods Data of a hospital based case-control study including 444 PD patients and 876 ag...

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Published in:Parkinsonism & related disorders 2015-06, Vol.21 (6), p.635-639
Main Authors: van der Mark, Marianne, Vermeulen, Roel, Nijssen, Peter C.G, Mulleners, Wim M, Sas, Antonetta M.G, van Laar, Teus, Huss, Anke, Kromhout, Hans
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Case-Control Studies
Female
Humans
Male
Metals
Metals - adverse effects
Middle Aged
Neurology
Occupational Exposure - adverse effects
Occupational exposures
Parkinson Disease - etiology
Parkinson's disease
Risk Factors
Solvents
Solvents - adverse effects
Surveys and Questionnaires
Welding
Welding - statistics & numerical data
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Summary:Abstract Objectives The aim of this study was to investigate the potential association between occupational exposure to solvents, metals and/or welding fumes and risk of developing Parkinson's disease (PD). Methods Data of a hospital based case-control study including 444 PD patients and 876 age and sex matched controls was used. Occupational histories and lifestyle information of cases and controls were collected in a structured telephone interview. Exposures to aromatic solvents, chlorinated solvents and metals were estimated by linking the ALOHA+ job-exposure matrix to the occupational histories. Exposure to welding fumes was estimated using self-reported information on welding activities. Results No statistically significant associations with any of the studied metal and solvent exposures were found. However, for self-reported welding activities we observed non-statistically significant reduced risk estimates (third tertile cumulative exposure: OR = 0.51 (95% CI: 0.21–1.24)). Conclusions The results of our study did not provide support for an increased chance on developing PD after occupational exposure to aromatic solvents, chlorinated solvents or exposure to metals. The results showed reduced risk estimates for welding, which is in line with previous research, but no clear explanation for these findings is available.
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2015.03.025