Maternal Deprivation and Early Weaning Modulate Experimental Allergic Encephalomyelitis in the Rat

The present experiment deals with the effect of maternal deprivation (MD) and early weaning (EW) on the development and course of experimental allergic encephalomyelitis (EAE) in Dark August (DA) rats. Five litters (five to nine pups per liter) were subjected to MD (4 h daily) from Day 1 until Day 2...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 1995-03, Vol.9 (1), p.9-19
Main Authors: Laban, O., Markovic, B.M., Dimitrijevic, M., Jankovic, B.D.
Format: Article
Language:English
Subjects:
Age Factors
Animals
Autoimmune Diseases - immunology
Autoimmune Diseases - psychology
Body Weight
Brain - pathology
Encephalomyelitis, Autoimmune, Experimental - immunology
Encephalomyelitis, Autoimmune, Experimental - psychology
Female
Guinea Pigs
Immunity, Maternally-Acquired
Male
Maternal Deprivation
Myelin Basic Protein - immunology
Myelin Basic Protein - toxicity
Psychoneuroimmunology
Rats - immunology
Rats - psychology
Sex Factors
Spinal Cord - immunology
Spinal Cord - pathology
Stress, Psychological - immunology
Weaning
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Summary:The present experiment deals with the effect of maternal deprivation (MD) and early weaning (EW) on the development and course of experimental allergic encephalomyelitis (EAE) in Dark August (DA) rats. Five litters (five to nine pups per liter) were subjected to MD (4 h daily) from Day 1 until Day 28. EW rats were weaned on Day 15 (EW-15, five litters) or Day 21 (EW-21, four litters). Control rats and MD rats were weaned on Day 28. At the age of 8 weeks, rats were immunized with guinea pig spinal cord in complete Freund′s adjuvant and clinical signs of EAE were recorded daily. On Day 18 after immunization, rats were bled and sacrificed. Brain and spinal cord were examined histologically for EAE lesions. Serum anti-rat myelin basic protein (MBP) antibodies were detected by ELISA. MD female rats exhibited suppression of neurological and histological signs of EAE in comparison with control rats. MD and control females showed elevated anti-MBP antibody level compared to MD and control males. EW-15 female rats demonstrated potentiation of neurological signs of EAE compared to control females. EW-21 females developed more severe clinical signs and histological lesions compared to control females. These results show that neonatal experiences, such as maternal deprivation and early weaning, influence the development of EAE in adult DA rats.
ISSN:0889-1591
1090-2139
DOI:10.1006/brbi.1995.1002