An intrinsic CRF signaling system within the optic tectum

Highlights • CRF and CRF R1 mRNAs are expressed in the optic tectum of X. laevis. • [125 I]-Tyr-oCRF binding sites in optic tectum are displaced by CRF R1 antagonists. • CRF acts on CRF R1 receptors in optic tectum to increases expression of Rgs2. • CRF has no effect on GABA or glutamate release fro...

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Published in:General and comparative endocrinology 2013-07, Vol.188, p.204-211
Main Authors: Carr, James A, Zhang, Bo, Li, Wenjie, Gao, Mamie, Garcia, Carlos, Lustgarten, Jacob, Wages, Mike, Smith, Ernest E
Format: Article
Language:English
Subjects:
Amphibian
Animals
antagonists
Anura
Anura - metabolism
Appetite
Appetite - drug effects
brain stem
cell membranes
Eating - drug effects
Endocrinology & Metabolism
explants
food intake
frogs
G-proteins
gamma-aminobutyric acid
gene expression
glutamic acid
hypothalamus
messenger RNA
norepinephrine
Pyrimidines - pharmacology
Pyrroles - pharmacology
radioimmunoassays
Real-Time Polymerase Chain Reaction
reverse transcriptase polymerase chain reaction
RNA, Messenger - metabolism
secretion
Signal Transduction - drug effects
Stress
Superior Colliculi - metabolism
thalamus
Vision
Xenopus laevis
Xenopus laevis - metabolism
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Summary:Highlights • CRF and CRF R1 mRNAs are expressed in the optic tectum of X. laevis. • [125 I]-Tyr-oCRF binding sites in optic tectum are displaced by CRF R1 antagonists. • CRF acts on CRF R1 receptors in optic tectum to increases expression of Rgs2. • CRF has no effect on GABA or glutamate release from tectum but acts on CRF R1 receptors to inhibit norepinephrine release. • CRF is released from optic tectum in a depolarization and calcium dependent manner.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2013.03.020