APRIL levels strongly correlate with IL-17 in systemic lupus erythematosus

Introduction Activated self-reactive B cells play an important part in systemic lupus erythematosus (SLE). A proliferation-inducing ligand (APRIL) and B cell-activating factor (BAFF) are B-cell specific stimulators, but activate B cells through different receptors. We investigated the reciprocal ass...

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Bibliographic Details
Published in:Lupus 2014-11, Vol.23 (13), p.1383-1391
Main Authors: Eilertsen, GØ, Nossent, J C
Format: Article
Language:English
Subjects:
Antibodies
Anticoagulants
Antigens
Autoantibodies - blood
B-Cell Activating Factor - blood
Blood
Case-Control Studies
Cells
Clinical medicine
Cross-Sectional Studies
Cytokines
Disease
Enzymes
Female
Females
Humans
Immunologic Factors - therapeutic use
Immunology
Interleukin-17 - blood
Ligands
Lupus
Lupus Erythematosus, Systemic - drug therapy
Lupus Erythematosus, Systemic - immunology
Male
Middle Aged
Severity of Illness Index
Tumor Necrosis Factor Ligand Superfamily Member 13 - blood
Tumor necrosis factor-TNF
White people
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Summary:Introduction Activated self-reactive B cells play an important part in systemic lupus erythematosus (SLE). A proliferation-inducing ligand (APRIL) and B cell-activating factor (BAFF) are B-cell specific stimulators, but activate B cells through different receptors. We investigated the reciprocal association between serum APRIL (s-APRIL), serum BAFF (s-BAFF) and immunological and clinical findings in SLE patients. Methods A cross-sectional case-control study was performed in 100 SLE patients (87% female, age 49 years, disease duration 12 years). APRIL and BAFF levels were measured by sandwich ELISA, compared with healthy controls and correlated with autoantibody, cytokine (IL-6 and IL-17) and clinical findings through nonparametric and multivariate regression analyses. Results Both median s-APRIL (478 vs. 0 pg/ml, p = 0.01) and s-BAFF (1720 vs. 0.9 pg/ml, p 
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203314543914