Systemic lupus erythematosus complicated with liver cirrhosis in a patient with Papillon-Lefèvre syndrome

We report the first case of a girl who presented with Papillon-Lefèvre syndrome (PLS) and subsequently developed systemic lupus erythematosus and liver cirrhosis. This indicates that autoimmune diseases can be a complication in patients with PLS. Cathepsin C gene mutations were not found in our pati...

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Bibliographic Details
Published in:Lupus 2014-12, Vol.23 (14), p.1523-1527
Main Authors: Yasudo, H, Ando, T, Takeuchi, M, Nakano, H, Itonaga, T, Takehara, H, Isojima, T, Miura, K, Harita, Y, Takita, J, Oka, A
Format: Article
Language:English
Subjects:
Antibodies
Anticoagulants
Antigens
Biopsy
Child
Female
Gum disease
Hepatitis C
Hepatitis, Autoimmune - complications
Hospitals
Humans
Hyaluronic acid
Immunology
Laboratories
Liver cirrhosis
Liver Cirrhosis - etiology
Liver Cirrhosis - pathology
Lupus
Lupus Erythematosus, Systemic - etiology
Lymphocytes
Mutation
Neutrophils
Papillon-Lefevre Disease - complications
Papillon-Lefevre Disease - genetics
Patients
Pediatrics
Purpura
Smooth muscle
Teeth
University graduates
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Summary:We report the first case of a girl who presented with Papillon-Lefèvre syndrome (PLS) and subsequently developed systemic lupus erythematosus and liver cirrhosis. This indicates that autoimmune diseases can be a complication in patients with PLS. Cathepsin C gene mutations were not found in our patient or her mother. Thus, other genetic factors may have been involved in this patient.
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203314547794