Lack of confirmation of anti-inward rectifying potassium channel 4.1 antibodies as reliable markers of multiple sclerosis

Background: auto-antibodies against the potassium channel inward rectifying potassium channel 4.1 (Kir4.1) have previously been identified in 46% of patients with multiple sclerosis (MS). Objectives: to confirm these findings. Methods: we evaluated the presence of anti-Kir4.1 antibodies by enzyme-li...

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Published in:Multiple sclerosis 2014-11, Vol.20 (13), p.1699-1703
Main Authors: Nerrant, Elodie, Salsac, Céline, Charif, Mahmoud, Ayrignac, Xavier, Carra-Dalliere, Clarisse, Castelnovo, Giovanni, Goulabchand, Radjiv, Tisseyre, Julie, Raoul, Cédric, Eliaou, Jean-François, Labauge, Pierre, Vincent, Thierry
Format: Article
Language:English
Subjects:
Adult
Autoantibodies - blood
Autoantibodies - immunology
Autoantigens - immunology
Biomarkers - analysis
Enzyme-Linked Immunosorbent Assay
Female
Fluorescent Antibody Technique
Humans
Male
Multiple Sclerosis - blood
Multiple Sclerosis - immunology
Potassium Channels, Inwardly Rectifying - immunology
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Summary:Background: auto-antibodies against the potassium channel inward rectifying potassium channel 4.1 (Kir4.1) have previously been identified in 46% of patients with multiple sclerosis (MS). Objectives: to confirm these findings. Methods: we evaluated the presence of anti-Kir4.1 antibodies by enzyme-linked immunosorbent assay (ELISA) and immunofluorescence in 268 MS patients, 46 patients with other neurological diseases (OND) and 45 healthy controls. Results: anti-Kir4.1 antibodies were found in 7.5% of MS patients, 4.3% of OND patients and 4.4% of healthy controls. Immunofluorescence analysis did not identify any specific staining. Conclusions: we confirmed the presence of anti-Kir4.1 antibodies in MS patients, but at a much lower prevalence than previously reported.
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458514531086