Thyroid hormone deiodinase type 2 mRNA levels in sea lamprey ( Petromyzon marinus ) are regulated during metamorphosis and in response to a thyroid challenge

Highlights ► A deiodinase type 2 (D2) cDNA was isolated and sequenced from Petromyzon marinus . ► P. marinus D2 mRNA is the longest yet reported (>9 Kb). ► D2 mRNA levels in the liver and intestine vary during P. marinus metamorphosis. ► Intestinal and hepatic D2 mRNA levels were altered in respo...

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Bibliographic Details
Published in:General and comparative endocrinology 2013-03, Vol.183, p.63-68
Main Authors: Stilborn, S. Salina M, Manzon, Lori A, Schauenberg, Jennifer D, Manzon, Richard G
Format: Article
Language:English
Subjects:
amphibians
Animals
blood serum
Cloning, Molecular
complementary DNA
Deiodinase type 2
Development
Endocrinology & Metabolism
Fish Proteins - genetics
Fish Proteins - metabolism
Gene Expression Regulation, Developmental
Homeostasis
Intestinal Mucosa - metabolism
Iodide Peroxidase - chemistry
Iodide Peroxidase - genetics
Iodide Peroxidase - metabolism
Iodothyronine Deiodinase Type II
Lamprey
Lampreys - genetics
Lampreys - metabolism
Larva - drug effects
larvae
liver
Liver - metabolism
messenger RNA
Metamorphosis
Metamorphosis, Biological - genetics
Northern blotting
Perchlorates - pharmacology
Petromyzon marinus
Petromyzontidae
potassium
Potassium Compounds - pharmacology
quantitative polymerase chain reaction
RNA, Messenger - metabolism
selenocysteine
Sequence Analysis, RNA
Thyroid hormone
thyroid hormones
Thyroid Hormones - metabolism
Thyroid Hormones - pharmacology
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Summary:Highlights ► A deiodinase type 2 (D2) cDNA was isolated and sequenced from Petromyzon marinus . ► P. marinus D2 mRNA is the longest yet reported (>9 Kb). ► D2 mRNA levels in the liver and intestine vary during P. marinus metamorphosis. ► Intestinal and hepatic D2 mRNA levels were altered in response to thyroid challenges.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2012.12.007