The use of angiogenic and antiangiogenic factors in the differential diagnosis of pre-eclampsia, antiphospholipid syndrome nephropathy and lupus nephritis

Pre-eclampsia (PE) is a major cause of maternal mortality and morbidity, perinatal deaths, preterm birth and intrauterine growth restriction. Differential diagnosis with antiphospholipid syndrome (APS) nephropathy and systemic lupus erythematosus (SLE) nephritis during pregnancy is difficult, if not...

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Bibliographic Details
Published in:Lupus 2014-10, Vol.23 (12), p.1299-1301
Main Authors: de Jesus, GR, de Jesus, NR, Levy, RA, Klumb, EM
Format: Article
Language:English
Subjects:
Antigens, CD - blood
Antiphospholipid Syndrome - blood
Antiphospholipid Syndrome - complications
Diagnosis, Differential
Disease
Endoglin
Female
Humans
Hypertension
Kidney Diseases - blood
Kidney Diseases - diagnosis
Kinases
Lupus
Lupus Nephritis - blood
Lupus Nephritis - diagnosis
Maternal mortality
Membrane Proteins - blood
Pre-Eclampsia - blood
Pre-Eclampsia - diagnosis
Preeclampsia
Pregnancy
Premature birth
Receptors, Cell Surface - blood
Thrombosis
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - blood
Vascular Endothelial Growth Factor Receptor-1 - blood
Womens health
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Summary:Pre-eclampsia (PE) is a major cause of maternal mortality and morbidity, perinatal deaths, preterm birth and intrauterine growth restriction. Differential diagnosis with antiphospholipid syndrome (APS) nephropathy and systemic lupus erythematosus (SLE) nephritis during pregnancy is difficult, if not sometimes impossible, as all three diseases may present hypertension and proteinuria. Improvement in diagnosis of PE has also offered new paths for differential diagnosis with other conditions and the analysis of angiogenic (vascular endothelial growth factor, placental growth factor) and antiangiogenic factors (serum soluble fms-like tyrosine kinase 1, soluble endoglin) is promising for differentiation between PE, APS nephropathy and SLE nephritis. This article reviews published studies about those factors in non-pregnant and pregnant patients with APS and SLE, comparing with patterns described in PE.
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203314529172