Novel 1,4-Substituted-1,2,3-Triazoles as Antitubercular Agents

Tuberculosis (TB) remains a pressing unmet medical need, particularly with the emergence of multidrug‐resistant and extensively drug‐resistant tuberculosis. Here, a series of 1,4‐substituted‐1,2,3‐triazoles have been synthesized and evaluated as potential antitubercular agents. These compounds were...

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Bibliographic Details
Published in:ChemMedChem 2015-05, Vol.10 (5), p.787-791
Main Authors: Altimari, Jarrad M., Hockey, Samantha C., Boshoff, Helena I., Sajid, Andaleeb, Henderson, Luke C.
Format: Article
Language:English
Subjects:
antibacterial agents
Antitubercular Agents - chemical synthesis
Antitubercular Agents - chemistry
Antitubercular Agents - pharmacology
azides
click chemistry
Dose-Response Relationship, Drug
Medical research
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium tuberculosis
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - growth & development
Structure-Activity Relationship
triazoles
Triazoles - chemical synthesis
Triazoles - chemistry
Triazoles - pharmacology
Tuberculosis
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Summary:Tuberculosis (TB) remains a pressing unmet medical need, particularly with the emergence of multidrug‐resistant and extensively drug‐resistant tuberculosis. Here, a series of 1,4‐substituted‐1,2,3‐triazoles have been synthesized and evaluated as potential antitubercular agents. These compounds were assembled via click chemistry in high crude purity and in moderate to high yield. Of the compounds tested, 12 compounds showed promising antitubercular activity with six possessing minimum inhibitory concentration (MIC) values
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.201500051