Comparative clinical evaluation on herbal formulation Pepsil, Safoof-e-Katira and Omeprazole in gastro esophageal reflux disease

This study was conducted to evaluate the role of Unani herbal drugs Pepsil and Safoof-e-katira on the gastro esophageal reflux disease (GERD). This was multicentre randomized case control study conducted at Matab Hakeem Muhammad Noor-ud-din, Burewala; Aziz Muhammad din Medical and Surgical Centre, B...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2015-05, Vol.28 (3), p.863-870
Main Authors: Toseef, Muhammad Umar, Saeed, Aftab, Mohi-Ud-Din, Ejaz, Usmanghani, Khan, Nazar, Halima, Nawaz, Allah, Ahmad, Irshad, Siddiqui, Faheem Ahmed
Format: Article
Language:English
Subjects:
Astragalus gummifer
Care and treatment
Coriandrum
Deglutition Disorders - drug therapy
Deglutition Disorders - etiology
Female
Gastroesophageal reflux
Gastroesophageal Reflux - complications
Gastroesophageal Reflux - drug therapy
Heartburn - drug therapy
Heartburn - etiology
Herbal medicine
Humans
Male
Omeprazole
Omeprazole - therapeutic use
Patient outcomes
Phyllanthus
Phytotherapy
Plant Preparations - therapeutic use
Plantago
Proton Pump Inhibitors - therapeutic use
Tragacanth
Treatment Outcome
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Summary:This study was conducted to evaluate the role of Unani herbal drugs Pepsil and Safoof-e-katira on the gastro esophageal reflux disease (GERD). This was multicentre randomized case control study conducted at Matab Hakeem Muhammad Noor-ud-din, Burewala; Aziz Muhammad din Medical and Surgical Centre, Burewala and Shifa-ul-mulk Memorial Hospital, Hamdard University Karachi. The patients were selected according to inclusion and exclusion criteria. In test group-1 the male female ratio was 40%, 60%; test group-2 was 42%, 58% and in control group was 44%, 56% respectively. The observed symptoms in the study were increased appetite (TG-1-95%, TG-2-95% and CG-89%), difficulty in swallowing (TG-1-93%, TG-2-96% and TC-94%), belching/burping (TG-1-97%, TG-2-97% and CG-95%), vomiting (TG-1-90%, TG-2-96% and CG-89%), heart burn (TG-1-100%, TG-2-100% and CG-98%), palpitation (TG-1-100%, TG-2-100% and CG-97%), epigastric pain (TG-1-97%, TG-2-97% and CG-90%), abdominal cramps (TG-1-97%, TG-2-98% and CG-95%), tenesmus (TG-1-100%, TG-2-100% and CG-97%), flatulence (TG-1-100%, TG-2-75% and CG-95%), wakeup during sleep (TG-1-94%, TG-2-87% and CG-94%). The p-value of the results of the symptoms was 0.000 except flatulence where the value was 0.001. The statistical results of the study prescribed that all the drugs studied (Pepsil, Safoof-e-katira and Omeprazole) are highly significant. The herbal coded drug Pepsil showed no side effects and unani herbal drug safoof-e-katira showed minimum result of 75% in the patients while Omeprazole resulted with some side effects. In the result it can be concluded that the herbal coded drug Pepsil is a potent herbal drug for gastro esophageal reflux disease.
ISSN:1011-601X