Association between Hemodynamically Significant Patent Ductus Arteriosus and Bronchopulmonary Dysplasia

• Published in: The Journal of pediatrics 2015-06, Vol.166 (6), p.1488-1492
• Main Authors: Schena, Federico, MD, Francescato, Gaia, MD, PhD, Cappelleri, Alessia, MD, Picciolli, Irene, MD, Mayer, Alessandra, MD, Mosca, Fabio, MD, Fumagalli, Monica, MD
• Format: Article
• Language: English
• Subjects: Bronchopulmonary Dysplasia - epidemiology; Bronchopulmonary Dysplasia - etiology; Ductus Arteriosus, Patent - complications; Ductus Arteriosus, Patent - physiopathology; Female; Hemodynamics; Humans; Incidence; Infant; Infant, Newborn; Male; Pediatrics; Retrospective Studies; Severity of Illness Index; Time Factors
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2015.03.012

Objective To assess whether the duration and magnitude of the shunt with patent ductus arteriosus (PDA) are related to a higher incidence of bronchopulmonary dysplasia (BPD) or death. Study design A total of 242 infants ≤28 weeks gestational age were evaluated retrospectively between 2007 and 2012; 105 (43.3%) developed BPD or died (group 1) and 137 (56.6%) did not (group 2). A review of all echocardiographic evaluations performed from birth up to 36 weeks of postconceptional age or final ductal closure was carried out, to detect the presence of PDA, and estimate the severity of ductal shunt through the “PDA staging system” proposed by McNamara and Sehgal. Results Group 1 presented with a hemodynamically significant ductus arteriosus (DA) (E3 and/or E4-PDA) for a longer period of time vs group 2: 4.8 vs 2.3 days, respectively ( P