Esmolol Added in Repeated, Cold, Oxygenated Blood Cardioplegia Improves Myocardial Function After Cardiopulmonary Bypass

Objective This study investigated if the β-receptor blocking agent esmolol, added to standard oxygenated blood cardioplegia, improved myocardial function after weaning from bypass. Design A block-randomized, blinded study. Setting A university laboratory. Participants Twenty anesthetized pigs, Norwe...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cardiothoracic and vascular anesthesia 2015-06, Vol.29 (3), p.684-693
Main Authors: Dahle, Geir O., MD, Salminen, Pirjo-Riitta, MD, Moen, Christian A., MD, PhD, Eliassen, Finn, CCP, Jonassen, Anne K., MSc, PhD, Haaverstad, Rune, MD, PhD, Matre, Knut, MSc, PhD, Grong, Ketil, MD, PhD
Format: Article
Language:English
Subjects:
Adrenergic beta-1 Receptor Antagonists - administration & dosage
Adrenergic beta-1 Receptor Antagonists - metabolism
Anesthesia & Perioperative Care
Animals
beta-blockade
cardiac function
cardioplegia
Cardioplegic Solutions - administration & dosage
Cardioplegic Solutions - metabolism
cardiopulmonary bypass
Cardiopulmonary Bypass - methods
Cardiopulmonary Bypass - trends
Cold Temperature
Critical Care
esmolol
Female
Heart Arrest, Induced - methods
Heart Arrest, Induced - trends
Male
Oxygen - administration & dosage
Oxygen - metabolism
Propanolamines - administration & dosage
Propanolamines - metabolism
Random Allocation
Swine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective This study investigated if the β-receptor blocking agent esmolol, added to standard oxygenated blood cardioplegia, improved myocardial function after weaning from bypass. Design A block-randomized, blinded study. Setting A university laboratory. Participants Twenty anesthetized pigs, Norwegian Landrace. Interventions After cardiopulmonary bypass, cardiac arrest was induced with cold (12°C), oxygenated blood cardioplegia, enriched with either esmolol or vehicle, repeated every 20 minutes. After 100 minutes the heart was reperfused and weaned. Measurements and Main Results Left ventricular function was evaluated with pressure-volume loops, local myocardial function with multilayer strain and strain rate by epicardial short-axis tissue Doppler imaging. One hour after declamping, preload recruitable stroke work did not differ between groups, but increased to 72±3 mmHg in esmolol-treated animals v 57±4 mmHg (p
ISSN:1053-0770
1532-8422
DOI:10.1053/j.jvca.2014.09.017