The effect of nifedipine on retinal venous pressure of glaucoma patients with the Flammer-Syndrome

Purpose The purpose was to measure the retinal venous pressure (RVP) in both eyes of primary open-angle glaucoma (POAG) patients before and 3 weeks after treatment with low-dosed Nifedipine. Methods This retrospective study included 20 POAG patients who were treated with Nifedipine (5 mg daily) and...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2015-06, Vol.253 (6), p.935-939
Main Authors: Fang, L., Turtschi, S., Mozaffarieh, Maneli
Format: Article
Language:English
Subjects:
Administration, Oral
Aged
Blood Flow Velocity - physiology
Blood Pressure - physiology
Calcium Channel Blockers - therapeutic use
Endothelin-1 - antagonists & inhibitors
Female
Glaucoma
Glaucoma, Open-Angle - drug therapy
Glaucoma, Open-Angle - physiopathology
Humans
Intraocular Pressure - physiology
Male
Medicine
Medicine & Public Health
Middle Aged
Nifedipine - therapeutic use
Ophthalmodynamometry
Ophthalmology
Regional Blood Flow
Retinal Diseases - physiopathology
Retinal Vein - physiopathology
Retrospective Studies
Tonometry, Ocular
Venous Pressure - physiology
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Summary:Purpose The purpose was to measure the retinal venous pressure (RVP) in both eyes of primary open-angle glaucoma (POAG) patients before and 3 weeks after treatment with low-dosed Nifedipine. Methods This retrospective study included 20 POAG patients who were treated with Nifedipine (5 mg daily) and 20 untreated control POAG patients. In both the treated and untreated control group, a distinction was made between those patients who had the Flammer-Syndrome (FS) and those who did not. The RVP was measured in all patients bilaterally at baseline and 3 weeks later by means of contact lens ophthalmodynamometry and the RVP measurements of the treated POAG patients were compared to the RVPs of the untreated POAG controls. Ophthalmodynamometry is done by applying an increasing force on the eye via a contact lens. The minimum force required to induce a venous pulsation is called the ophthalmodynamometric force (ODF). The RVP is defined and calculated as the sum of ODF and intraocular pressure (IOP) [RVP = ODF + IOP]. Results The RVP decreased significantly after 3 weeks in both eyes of patients treated with low-dosed Nifedipine compared to the untreated group (mean decrease of 12.5 mmHg (SD 12.5), P  
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-015-3001-7