Antioxidant and antitumor activities in vitro of polysaccharides from E. sipunculoides

Three polysaccharides (SAP30, SAP60 and SAP80) were separated from the body of Edwardsia sipunculoides by tissue homogenate and papain hydrolysis. Total soluble sugar contents, monosaccharide compositions, antioxidant and antitumor activities in vitro of those polysaccharides were investigated, resp...

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Bibliographic Details
Published in:International journal of biological macromolecules 2015-07, Vol.78, p.56-61
Main Authors: He, Rongjun, Zhao, Yuejun, Zhao, Ruina, Sun, Peilong
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antioxidant
Antioxidants - chemistry
Antioxidants - pharmacology
Antitumor
Cell Line, Tumor
Cell Proliferation - drug effects
E. sipunculoides
Humans
Polysaccharide
Polysaccharides - chemistry
Polysaccharides - pharmacology
Sea Anemones - chemistry
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Summary:Three polysaccharides (SAP30, SAP60 and SAP80) were separated from the body of Edwardsia sipunculoides by tissue homogenate and papain hydrolysis. Total soluble sugar contents, monosaccharide compositions, antioxidant and antitumor activities in vitro of those polysaccharides were investigated, respectively. Results showed that the total soluble sugar contents of SAP composed of Man, GlcN, Rha, GalN, GlcUA, Glc, Gal, Xyl and Fuc were more than 85% estimated by the phenol-sulfuric acid assay. In addition, SAP had potential antioxidant and antitumor activities. SAP30 has the most significant antitumor effect. This study suggested that SAP could be a potential natural antioxidants and antitumor agents.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2015.03.030