Vitamin D Supplementation in Nursing Home Patients: Randomized Controlled Trial of Standard Daily Dose Versus Individualized Loading Dose Regimen

Background Supplementation of cholecalciferol 800 IU daily appears to be insufficient to raise vitamin D levels to >75 nmol/l in nursing home (NH) patients. Objective Our objective was to compare the efficacy of an individualized cholecalciferol loading dose (LD) regimen and a daily dose (DD) reg...

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Bibliographic Details
Published in:Drugs & aging 2015-05, Vol.32 (5), p.371-378
Main Authors: Wijnen, Hugo, Salemink, Dayenne, Roovers, Lian, Taekema, Diana, de Boer, Hans
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Algorithms
Body Weight
Cholecalciferol - administration & dosage
Cholecalciferol - therapeutic use
Dietary Supplements
Endpoint Determination
Female
Geriatrics/Gerontology
Hand Strength
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Nursing Homes
Patients
Pharmacology/Toxicology
Pharmacotherapy
Precision Medicine - methods
Reference Standards
Short Communication
Treatment Outcome
Vitamin D - administration & dosage
Vitamin D - therapeutic use
Vitamin D Deficiency - complications
Vitamins - administration & dosage
Vitamins - therapeutic use
Walking
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Summary:Background Supplementation of cholecalciferol 800 IU daily appears to be insufficient to raise vitamin D levels to >75 nmol/l in nursing home (NH) patients. Objective Our objective was to compare the efficacy of an individualized cholecalciferol loading dose (LD) regimen and a daily dose (DD) regimen of cholecalciferol 800 IU in reaching 25-OH vitamin D (25OHD) levels >75 nmol/l. Methods A total of 30 NH patients with 25OHD levels 75 nmol/l at T 5 . Secondary endpoints were the proportion of patients with 25OHD levels >75 nmol/l at T 26 , safety of LD regimen, and improvement of performance tests with normalization of vitamin D levels. Results Median baseline 25OHD levels (interquartile range) were comparable between the 14 DD and 16 LD patients: 20.9 (15.9–29.6) and 21.7 (16.4–32.8) nmol/l, respectively. Levels of 25OHD >75 nmol/l at T 5 were reached in 79 % of the 14 LD patients, but in none of the 13 DD patients ( p  75 nmol/l were reached in 83 % of the 12 LD patients and in 30 % of the ten DD patients ( p  
ISSN:1170-229X
1179-1969
DOI:10.1007/s40266-015-0259-8