The relationship between the high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) and coronary in-stent restenosis

High-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) contributed to several beneficial effects in the cardiovascular system. We explored the relationship between the HDL-S1P concentrations and coronary in-stent restenosis (ISR). Fifty consecutive patients with ISR and 50 normal co...

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Bibliographic Details
Published in:Clinica chimica acta 2015-06, Vol.446, p.248-252
Main Authors: Jing, Xiao-Dong, Wei, Xiao-Ming, Deng, Song-Bai, Du, Jian-Lin, Liu, Ya-Jie, She, Qiang
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
Case-Control Studies
Coronary Artery Disease - blood
Coronary Artery Disease - pathology
Coronary Artery Disease - surgery
Coronary Restenosis - blood
Coronary Restenosis - diagnosis
Coronary Restenosis - pathology
Female
High-density lipoprotein
Humans
In-stent restenosis
Inflammation
Lipoproteins, HDL - blood
Logistic Models
Lysophospholipids - blood
Male
Middle Aged
Risk Factors
ROC Curve
Sphingosine - analogs & derivatives
Sphingosine - blood
Sphingosine-1-phosphate
Stents
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Summary:High-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) contributed to several beneficial effects in the cardiovascular system. We explored the relationship between the HDL-S1P concentrations and coronary in-stent restenosis (ISR). Fifty consecutive patients with ISR and 50 normal control subjects were included. The serum S1P, HDL-S1P and clinical data were collected to explore the relationships between these parameters and ISR. The patients with ISR had significantly lower concentrations of serum S1P (96.10±26.33 vs. 113.40±32.72; P=0.004) and HDL-S1P (32.81±10.02 vs. 42.72±11.75; P
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2015.04.038