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The relationship between the high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) and coronary in-stent restenosis
High-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) contributed to several beneficial effects in the cardiovascular system. We explored the relationship between the HDL-S1P concentrations and coronary in-stent restenosis (ISR). Fifty consecutive patients with ISR and 50 normal co...
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| Published in: | Clinica chimica acta 2015-06, Vol.446, p.248-252 |
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| container_title | Clinica chimica acta |
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| creator | Jing, Xiao-Dong Wei, Xiao-Ming Deng, Song-Bai Du, Jian-Lin Liu, Ya-Jie She, Qiang |
| description | High-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) contributed to several beneficial effects in the cardiovascular system. We explored the relationship between the HDL-S1P concentrations and coronary in-stent restenosis (ISR).
Fifty consecutive patients with ISR and 50 normal control subjects were included. The serum S1P, HDL-S1P and clinical data were collected to explore the relationships between these parameters and ISR.
The patients with ISR had significantly lower concentrations of serum S1P (96.10±26.33 vs. 113.40±32.72; P=0.004) and HDL-S1P (32.81±10.02 vs. 42.72±11.75; P |
| doi_str_mv | 10.1016/j.cca.2015.04.038 |
| format | article |
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Fifty consecutive patients with ISR and 50 normal control subjects were included. The serum S1P, HDL-S1P and clinical data were collected to explore the relationships between these parameters and ISR.
The patients with ISR had significantly lower concentrations of serum S1P (96.10±26.33 vs. 113.40±32.72; P=0.004) and HDL-S1P (32.81±10.02 vs. 42.72±11.75; P<0.001). All included patients were divided into four quartiles based on their concentrations of HDL-S1P: Quartile 1 (18.63–28.51ng/ml), Quartile 2 (28.62–37.28ng/ml), Quartile 3 (37.35–45.27ng/ml), and Quartile 4 (45.59–79.36ng/ml). The rates of ISR were 84%, 48%, 40% and 28%, respectively. The patients in Quartile 1 exhibited significantly higher rates of ISR compared with the other groups (P=0.001). A multivariate stepwise logistic regression analysis indicated that HDL-S1P (OR=0.846, 95% CI=0.767–0.932, P=0.001) was an independent predictor of ISR. An ROC analysis indicated that HDL-S1P=30.37ng/ml and had a 90% sensitivity and a 52% specificity in predicting ISR.
HDL-S1P is an independent predictor of ISR, and patients with higher concentrations of HDL-S1P have a low risk of ISR.
•Detection of S1P and HDL-S1P in human serum by Liquid Chromatograph Mass Spectrometer•Patients with ISR have significantly lower levels of serum S1P and HDL-S1P.•HDL-S1P is an independent predictor of ISR, and patients with higher levels of HDL-S1P have a low risk of ISR.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cca.2015.04.038</identifier><identifier>PMID: 25958848</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aged ; Biomarkers - blood ; Case-Control Studies ; Coronary Artery Disease - blood ; Coronary Artery Disease - pathology ; Coronary Artery Disease - surgery ; Coronary Restenosis - blood ; Coronary Restenosis - diagnosis ; Coronary Restenosis - pathology ; Female ; High-density lipoprotein ; Humans ; In-stent restenosis ; Inflammation ; Lipoproteins, HDL - blood ; Logistic Models ; Lysophospholipids - blood ; Male ; Middle Aged ; Risk Factors ; ROC Curve ; Sphingosine - analogs & derivatives ; Sphingosine - blood ; Sphingosine-1-phosphate ; Stents</subject><ispartof>Clinica chimica acta, 2015-06, Vol.446, p.248-252</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-110352e3de80aabccc682b0f3bb3c769d8c4562143b2da6ac9dc2f5938661b6a3</citedby><cites>FETCH-LOGICAL-c353t-110352e3de80aabccc682b0f3bb3c769d8c4562143b2da6ac9dc2f5938661b6a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25958848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jing, Xiao-Dong</creatorcontrib><creatorcontrib>Wei, Xiao-Ming</creatorcontrib><creatorcontrib>Deng, Song-Bai</creatorcontrib><creatorcontrib>Du, Jian-Lin</creatorcontrib><creatorcontrib>Liu, Ya-Jie</creatorcontrib><creatorcontrib>She, Qiang</creatorcontrib><title>The relationship between the high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) and coronary in-stent restenosis</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>High-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) contributed to several beneficial effects in the cardiovascular system. We explored the relationship between the HDL-S1P concentrations and coronary in-stent restenosis (ISR).
Fifty consecutive patients with ISR and 50 normal control subjects were included. The serum S1P, HDL-S1P and clinical data were collected to explore the relationships between these parameters and ISR.
The patients with ISR had significantly lower concentrations of serum S1P (96.10±26.33 vs. 113.40±32.72; P=0.004) and HDL-S1P (32.81±10.02 vs. 42.72±11.75; P<0.001). All included patients were divided into four quartiles based on their concentrations of HDL-S1P: Quartile 1 (18.63–28.51ng/ml), Quartile 2 (28.62–37.28ng/ml), Quartile 3 (37.35–45.27ng/ml), and Quartile 4 (45.59–79.36ng/ml). The rates of ISR were 84%, 48%, 40% and 28%, respectively. The patients in Quartile 1 exhibited significantly higher rates of ISR compared with the other groups (P=0.001). A multivariate stepwise logistic regression analysis indicated that HDL-S1P (OR=0.846, 95% CI=0.767–0.932, P=0.001) was an independent predictor of ISR. An ROC analysis indicated that HDL-S1P=30.37ng/ml and had a 90% sensitivity and a 52% specificity in predicting ISR.
HDL-S1P is an independent predictor of ISR, and patients with higher concentrations of HDL-S1P have a low risk of ISR.
•Detection of S1P and HDL-S1P in human serum by Liquid Chromatograph Mass Spectrometer•Patients with ISR have significantly lower levels of serum S1P and HDL-S1P.•HDL-S1P is an independent predictor of ISR, and patients with higher levels of HDL-S1P have a low risk of ISR.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary Artery Disease - surgery</subject><subject>Coronary Restenosis - blood</subject><subject>Coronary Restenosis - diagnosis</subject><subject>Coronary Restenosis - pathology</subject><subject>Female</subject><subject>High-density lipoprotein</subject><subject>Humans</subject><subject>In-stent restenosis</subject><subject>Inflammation</subject><subject>Lipoproteins, HDL - blood</subject><subject>Logistic Models</subject><subject>Lysophospholipids - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Sphingosine - analogs & derivatives</subject><subject>Sphingosine - blood</subject><subject>Sphingosine-1-phosphate</subject><subject>Stents</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9UEtvEzEQthCIhsAP4IJ8TA9e_FrXK06oPIoUCSTK2fLak66jjb3YDlV_AP8bRykcOY1m5nvMfAi9ZrRjlKm3-84523HK-o7Kjgr9BK2YvhJEyIE_RStK6UD0oNkFelHKvrWSKvYcXfB-6LWWeoV-306AM8y2hhTLFBY8Qr0HiLi2xRTuJuIhllAf8ByWtORUIUS8ufmwvSS2lOSCreBxWaYQ71IJEQgjy5TaoC3w5jv7dolt9NilnKLNDzhEUirE2mxPtXHKS_RsZ-cCrx7rGv349PH2-oZsv37-cv1-S5zoRSWMUdFzEB40tXZ0zinNR7oT4yjclRq8drJXnEkxcm-VdYN3fNcPQivFRmXFGm3Ouu2Pn8dmbw6hOJhnGyEdi2FKS8kH2dzWiJ2hLqdSMuzMksOh3W8YNaf0zd609M0pfUOlaek3zptH-eN4AP-P8TfuBnh3BkB78leAbIoLEB34kMFV41P4j_wfTZqW7Q</recordid><startdate>20150615</startdate><enddate>20150615</enddate><creator>Jing, Xiao-Dong</creator><creator>Wei, Xiao-Ming</creator><creator>Deng, Song-Bai</creator><creator>Du, Jian-Lin</creator><creator>Liu, Ya-Jie</creator><creator>She, Qiang</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150615</creationdate><title>The relationship between the high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) and coronary in-stent restenosis</title><author>Jing, Xiao-Dong ; Wei, Xiao-Ming ; Deng, Song-Bai ; Du, Jian-Lin ; Liu, Ya-Jie ; She, Qiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-110352e3de80aabccc682b0f3bb3c769d8c4562143b2da6ac9dc2f5938661b6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary Artery Disease - surgery</topic><topic>Coronary Restenosis - blood</topic><topic>Coronary Restenosis - diagnosis</topic><topic>Coronary Restenosis - pathology</topic><topic>Female</topic><topic>High-density lipoprotein</topic><topic>Humans</topic><topic>In-stent restenosis</topic><topic>Inflammation</topic><topic>Lipoproteins, HDL - blood</topic><topic>Logistic Models</topic><topic>Lysophospholipids - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Sphingosine - analogs & derivatives</topic><topic>Sphingosine - blood</topic><topic>Sphingosine-1-phosphate</topic><topic>Stents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jing, Xiao-Dong</creatorcontrib><creatorcontrib>Wei, Xiao-Ming</creatorcontrib><creatorcontrib>Deng, Song-Bai</creatorcontrib><creatorcontrib>Du, Jian-Lin</creatorcontrib><creatorcontrib>Liu, Ya-Jie</creatorcontrib><creatorcontrib>She, Qiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jing, Xiao-Dong</au><au>Wei, Xiao-Ming</au><au>Deng, Song-Bai</au><au>Du, Jian-Lin</au><au>Liu, Ya-Jie</au><au>She, Qiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between the high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) and coronary in-stent restenosis</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>2015-06-15</date><risdate>2015</risdate><volume>446</volume><spage>248</spage><epage>252</epage><pages>248-252</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>High-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) contributed to several beneficial effects in the cardiovascular system. We explored the relationship between the HDL-S1P concentrations and coronary in-stent restenosis (ISR).
Fifty consecutive patients with ISR and 50 normal control subjects were included. The serum S1P, HDL-S1P and clinical data were collected to explore the relationships between these parameters and ISR.
The patients with ISR had significantly lower concentrations of serum S1P (96.10±26.33 vs. 113.40±32.72; P=0.004) and HDL-S1P (32.81±10.02 vs. 42.72±11.75; P<0.001). All included patients were divided into four quartiles based on their concentrations of HDL-S1P: Quartile 1 (18.63–28.51ng/ml), Quartile 2 (28.62–37.28ng/ml), Quartile 3 (37.35–45.27ng/ml), and Quartile 4 (45.59–79.36ng/ml). The rates of ISR were 84%, 48%, 40% and 28%, respectively. The patients in Quartile 1 exhibited significantly higher rates of ISR compared with the other groups (P=0.001). A multivariate stepwise logistic regression analysis indicated that HDL-S1P (OR=0.846, 95% CI=0.767–0.932, P=0.001) was an independent predictor of ISR. An ROC analysis indicated that HDL-S1P=30.37ng/ml and had a 90% sensitivity and a 52% specificity in predicting ISR.
HDL-S1P is an independent predictor of ISR, and patients with higher concentrations of HDL-S1P have a low risk of ISR.
•Detection of S1P and HDL-S1P in human serum by Liquid Chromatograph Mass Spectrometer•Patients with ISR have significantly lower levels of serum S1P and HDL-S1P.•HDL-S1P is an independent predictor of ISR, and patients with higher levels of HDL-S1P have a low risk of ISR.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25958848</pmid><doi>10.1016/j.cca.2015.04.038</doi><tpages>5</tpages></addata></record> |
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| ispartof | Clinica chimica acta, 2015-06, Vol.446, p.248-252 |
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| subjects | Aged Biomarkers - blood Case-Control Studies Coronary Artery Disease - blood Coronary Artery Disease - pathology Coronary Artery Disease - surgery Coronary Restenosis - blood Coronary Restenosis - diagnosis Coronary Restenosis - pathology Female High-density lipoprotein Humans In-stent restenosis Inflammation Lipoproteins, HDL - blood Logistic Models Lysophospholipids - blood Male Middle Aged Risk Factors ROC Curve Sphingosine - analogs & derivatives Sphingosine - blood Sphingosine-1-phosphate Stents |
| title | The relationship between the high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) and coronary in-stent restenosis |
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