Relationship between serum IgA/C3 ratio and severity of histological lesions using the Oxford classification in children with IgA nephropathy

Background The aim of this study was to evaluate the usefulness of serum immunoglobulin A/complement factor 3 (IgA/C3) ratio for predicting histological severity of kidney lesions in children with IgA nephropathy (IgAN) based on World Health Organization (WHO) and the Oxford classification (OC). Met...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2015-07, Vol.30 (7), p.1113-1120
Main Authors: Mizerska-Wasiak, Małgorzata, Małdyk, Jadwiga, Rybi-Szumińska, Agnieszka, Wasilewska, Anna, Miklaszewska, Monika, Pietrzyk, Jacek, Firszt-Adamczyk, Agnieszka, Stankiewicz, Roman, Bieniaś, Beata, Zajączkowska, Małgorzata, Gadomska-Prokop, Katarzyna, Grenda, Ryszard, Pukajło-Marczyk, Agnieszka, Zwolińska, Danuta, Szczepańska, Maria, Turczyn, Agnieszka, Roszkowska-Blaim, Maria
Format: Article
Language:English
Subjects:
Adolescent
Age of Onset
Atrophy
Biomarkers - analysis
Biopsy
Care and treatment
Child
Child, Preschool
Classification
Complement C3 - analysis
Development and progression
Female
Fibrosis
Genetic aspects
Glomerular Mesangium - pathology
Glomerulonephritis, IGA - blood
Glomerulonephritis, IGA - classification
Glomerulonephritis, IGA - pathology
Glomerulosclerosis, Focal Segmental - pathology
Hematuria
Humans
Hypertension
Iga glomerulonephritis
Immunoglobulin A - blood
Immunoglobulins
Infant
Kidney - pathology
Male
Medical records
Medicine
Medicine & Public Health
Microscopy
Nephrology
Original Article
Patient outcomes
Pediatrics
Predictive Value of Tests
Proteinuria - metabolism
Risk Factors
Urine
Urine - cytology
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The aim of this study was to evaluate the usefulness of serum immunoglobulin A/complement factor 3 (IgA/C3) ratio for predicting histological severity of kidney lesions in children with IgA nephropathy (IgAN) based on World Health Organization (WHO) and the Oxford classification (OC). Methods We studied 89 children with IgAN with a mean age of 11.38 ± 4.1 years (range 2–18 years). Based on available medical records, we retrospectively evaluated clinical data, IgA/C3 ratio, and kidney biopsy findings using the five-grade WHO classification and the OC The mesangial hypercellularity (M), endocapillary hypercellularity (E), segmental sclerosis (S), tubular atrophy/interstitial fibrosis (T) (MEST) score (absent = 0, present = 1) calculated as the sum of M+E+S+T ranging from 0 to 4. Results Mean IgA/C3 ratio values were significantly higher ( P  
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-014-3024-z