Nationwide reduction in the frequency of severe hypoglycemia by half

Aims To examine contemporary rates of severe hypoglycemia (SH) and identify the effect of predictors of SH in a pediatric type 1 diabetes population. Methods The national diabetes register provided data on children residing in Denmark from 2008 to 2013 in this register-based population study. Robust...

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Bibliographic Details
Published in:Acta diabetologica 2015-06, Vol.52 (3), p.591-599
Main Authors: Fredheim, S., Johansen, A., Thorsen, S. U., Kremke, B., Nielsen, L. B., Olsen, B. S., Lyngsøe, L., Sildorf, S. M., Pipper, C., Mortensen, H. B., Johannesen, J., Svensson, J.
Format: Article
Language:English
Subjects:
Adolescent
Child
Child, Preschool
Denmark - epidemiology
Diabetes
Diabetes Mellitus, Type 1 - drug therapy
Diabetes Mellitus, Type 1 - epidemiology
Female
Humans
Hypoglycemia
Hypoglycemia - drug therapy
Hypoglycemia - epidemiology
Insulin - administration & dosage
Internal Medicine
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Original Article
Pediatrics
Population genetics
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Summary:Aims To examine contemporary rates of severe hypoglycemia (SH) and identify the effect of predictors of SH in a pediatric type 1 diabetes population. Methods The national diabetes register provided data on children residing in Denmark from 2008 to 2013 in this register-based population study. Robust Poisson regression models were applied. Results The study population [ n  = 2,715 (50.9 % boys), mean (SD) age at onset; 8.1 (4.0) years, diabetes duration; 5.6 (4.9) years] comprised 7,390 person-years of data and 561 events of SH. The overall incidence of SH was 7.6 per 100 person-years. The incidence rate peaked with 16.0 per 100 person-years in 2008 reaching a nadir of 4.9 in 2011. Overall, insulin pump reduced the rate of SH with 27 % compared to any pen treatment ( P  = 0.003). When stratifying pen treatment, premixed insulin increased the rate of SH by 1.9-fold ( P  = 0.0015) and NPH increased the rate by 1.6-fold ( P  = 0.003) versus pump treatment, whereas long-acting insulin analogues were comparable with pump treatment ( P  = 0.1485). We found no association of SH with glycemic control ( P  > 0.05). Conclusions A nationwide halving in rates of severe hypoglycemia was observed during the study period independent of the prevailing average HbA1c level. Changes in diabetes care and successful educational programs may have influenced the lower incidence rate of severe hypoglycemia.
ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-014-0697-5