Galectin-9 as an important marker in the differential diagnosis between oral squamous cell carcinoma, oral leukoplakia and oral lichen planus

Abstract Objectives To evaluate the expression of Galectins (Gal) 1, 3 and 9, Metalloproteinase 3 (MMP-3) and mast cell density in oral lesions of patients with potentially malignant disorders (PMD) and oral squamous cell carcinomas (OSCC) by comparison with the controls. Study design We selected 40...

Full description

Saved in:
Bibliographic Details
Published in:Immunobiology (1979) 2015-08, Vol.220 (8), p.1006-1011
Main Authors: Muniz, Janusa Maria, Bibiano Borges, Cláudia Renata, Beghini, Marcela, de Araújo, Marcelo Sivieri, Miranda Alves, Polyanna, de Lima, Lilian Margareth Biagioni, Pereira, Sanívia Aparecida de Lima, Nogueira, Ruchele Dias, Napimoga, Marcelo Henrique, Rodrigues, Virmondes, Rodrigues, Denise Bertulucci Rocha
Format: Article
Language:English
Subjects:
Advanced Basic Science
Allergy and Immunology
Benzamides - metabolism
Biomarkers, Tumor - metabolism
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - pathology
Diagnosis, Differential
Galectin 3 - metabolism
Galectins
Galectins - metabolism
Humans
Immunohistochemistry
Leukoplakia - diagnosis
Lichen Planus - diagnosis
Mast cells
Mast Cells - immunology
Matrix Metalloproteinase 3 - metabolism
Metalloproteinases
Mouth Neoplasms - diagnosis
Mouth Neoplasms - pathology
Oral cancer
Potentially Malignant Disorders
Tyrosine - analogs & derivatives
Tyrosine - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Objectives To evaluate the expression of Galectins (Gal) 1, 3 and 9, Metalloproteinase 3 (MMP-3) and mast cell density in oral lesions of patients with potentially malignant disorders (PMD) and oral squamous cell carcinomas (OSCC) by comparison with the controls. Study design We selected 40 cases of PMD, 40 OSCC and 13 with normal histopathological profile. Immunohistochemistry was performed for Gal-1, Gal-3, Gal-9 and MMP-3. Results Gal-9 was significantly higher in patients with OSCC than in others groups ( p < 0.001). Gal-1 expression was significantly lower in patients with leukoplakia than those with OSCC and controls ( p = 0.0001). Gal-3 was significantly lower in patients with OSCC than those with leukoplakia ( p = 0.03). MMP-3 was lower in patients with leukoplakia in comparison with the lichen planus group ( p = 0.013). Conclusion The increased expression of Gal-9 may be helpful to differentiate of OSCC from other oral cavity lesions.
ISSN:0171-2985
1878-3279
DOI:10.1016/j.imbio.2015.04.004