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Immunohistochemical analysis of dichloroacetic acid (DCA)-induced hepatocarcinogenesis in male Fischer (F344) rats
We examined the incidence of proliferative lesions, hyperplastic nodules and altered hepatic foci, in male F344 rat liver, to determine their preneoplastic potential during dichloroacetic acid (DCA)-induced hepatocarcinogenesis. Immunohistochemical and image analysis methods were used to detect the...
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| Published in: | Cancer letters 1995-05, Vol.92 (1), p.67-76 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c417t-fdd9fd708860cb10c3a96e6ccacfe528894dad6639ae8e4960b358e4c19b68f53 |
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| cites | cdi_FETCH-LOGICAL-c417t-fdd9fd708860cb10c3a96e6ccacfe528894dad6639ae8e4960b358e4c19b68f53 |
| container_end_page | 76 |
| container_issue | 1 |
| container_start_page | 67 |
| container_title | Cancer letters |
| container_volume | 92 |
| creator | Richmond, R.E. Carter, J.H. Carter, H.W. Daniel, F.B. DeAngelo, A.B. |
| description | We examined the incidence of proliferative lesions, hyperplastic nodules and altered hepatic foci, in male F344 rat liver, to determine their preneoplastic potential during dichloroacetic acid (DCA)-induced hepatocarcinogenesis. Immunohistochemical and image analysis methods were used to detect the expression of 6 histochemical markers of neoplastic cells; p21
ras, p39 c-
jun, p55 c-
fos, aldehyde dehydrogenase (ALDH), glutathione s-transferase (GST-p), and alpha fetoprotein (AFP) during DCA-induced hepatocarcinogenesis. Our results were consistent with our previous data and suggested that the hyperplastic nodules, rather than altered hepatic foci, is a putative preneoplastic lesion during DCA-induced hepatocarcinogenesis in the male F344 rat. |
| doi_str_mv | 10.1016/0304-3835(94)03756-9 |
| format | article |
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ras, p39 c-
jun, p55 c-
fos, aldehyde dehydrogenase (ALDH), glutathione s-transferase (GST-p), and alpha fetoprotein (AFP) during DCA-induced hepatocarcinogenesis. Our results were consistent with our previous data and suggested that the hyperplastic nodules, rather than altered hepatic foci, is a putative preneoplastic lesion during DCA-induced hepatocarcinogenesis in the male F344 rat.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/0304-3835(94)03756-9</identifier><identifier>PMID: 7538896</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Aldehyde dehydrogenase ; Aldehyde Dehydrogenase - analysis ; Alpha fetoprotein ; alpha-Fetoproteins - analysis ; Animals ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Carcinogenesis, carcinogens and anticarcinogens ; Cell Division ; Chemical agents ; Dichloroacetic acid ; Dichloroacetic Acid - toxicity ; Experimental hepatocarcinogenesis ; Glutathione s-transferase ; Glutathione Transferase - analysis ; Immunoenzyme Techniques ; Liver Neoplasms - chemically induced ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Male ; Medical sciences ; Oncogene Protein p21(ras) - analysis ; p21 ras ; p39 c- jun ; p55 c- fos ; Proto-Oncogene Proteins c-fos - analysis ; Proto-Oncogene Proteins c-jun - analysis ; Rats ; Rats, Inbred F344 ; Tumors</subject><ispartof>Cancer letters, 1995-05, Vol.92 (1), p.67-76</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-fdd9fd708860cb10c3a96e6ccacfe528894dad6639ae8e4960b358e4c19b68f53</citedby><cites>FETCH-LOGICAL-c417t-fdd9fd708860cb10c3a96e6ccacfe528894dad6639ae8e4960b358e4c19b68f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3655896$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7538896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Richmond, R.E.</creatorcontrib><creatorcontrib>Carter, J.H.</creatorcontrib><creatorcontrib>Carter, H.W.</creatorcontrib><creatorcontrib>Daniel, F.B.</creatorcontrib><creatorcontrib>DeAngelo, A.B.</creatorcontrib><title>Immunohistochemical analysis of dichloroacetic acid (DCA)-induced hepatocarcinogenesis in male Fischer (F344) rats</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>We examined the incidence of proliferative lesions, hyperplastic nodules and altered hepatic foci, in male F344 rat liver, to determine their preneoplastic potential during dichloroacetic acid (DCA)-induced hepatocarcinogenesis. Immunohistochemical and image analysis methods were used to detect the expression of 6 histochemical markers of neoplastic cells; p21
ras, p39 c-
jun, p55 c-
fos, aldehyde dehydrogenase (ALDH), glutathione s-transferase (GST-p), and alpha fetoprotein (AFP) during DCA-induced hepatocarcinogenesis. Our results were consistent with our previous data and suggested that the hyperplastic nodules, rather than altered hepatic foci, is a putative preneoplastic lesion during DCA-induced hepatocarcinogenesis in the male F344 rat.</description><subject>Aldehyde dehydrogenase</subject><subject>Aldehyde Dehydrogenase - analysis</subject><subject>Alpha fetoprotein</subject><subject>alpha-Fetoproteins - analysis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Cell Division</subject><subject>Chemical agents</subject><subject>Dichloroacetic acid</subject><subject>Dichloroacetic Acid - toxicity</subject><subject>Experimental hepatocarcinogenesis</subject><subject>Glutathione s-transferase</subject><subject>Glutathione Transferase - analysis</subject><subject>Immunoenzyme Techniques</subject><subject>Liver Neoplasms - chemically induced</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oncogene Protein p21(ras) - analysis</subject><subject>p21 ras</subject><subject>p39 c- jun</subject><subject>p55 c- fos</subject><subject>Proto-Oncogene Proteins c-fos - analysis</subject><subject>Proto-Oncogene Proteins c-jun - analysis</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNp9kE1rGzEURUVpSJ2k_6AFLUqxF9NK0cdIm0Jw4yYQ6KZZC_npTa0yM3KlmUL-feXaeNmVBO_cy-UQ8o6zT5xx_ZkJJhthhFpauWKiVbqxr8iCm_a2aa1hr8nijLwhV6X8Yowp2apLctkqYYzVC5Ifh2Ee0y6WKcEOhwi-p370_UuJhaaOhgi7PuXkAacI1EMMdPl1fbdq4hhmwEB3uPc17DPEMf3EEQ_JONLB90g3sdTaTJcbIeWKZj-VG3LR-b7g29N7TZ439z_WD83T92-P67unBiRvp6YLwXahZcZoBlvOQHirUQN46FDd1vky-KC1sB4NSqvZVqj6AW632nRKXJOPx959Tr9nLJMb6hjsez9imovj2igppK6gPIKQUykZO7fPcfD5xXHmDqrdwaM7eHRWun-qna2x96f-eTtgOIdObuv9w-nuS7XaZT9CLGdMaKWO2JcjhtXFn4jZFYg4VrMxI0wupPj_HX8B9f2a_g</recordid><startdate>19950525</startdate><enddate>19950525</enddate><creator>Richmond, R.E.</creator><creator>Carter, J.H.</creator><creator>Carter, H.W.</creator><creator>Daniel, F.B.</creator><creator>DeAngelo, A.B.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19950525</creationdate><title>Immunohistochemical analysis of dichloroacetic acid (DCA)-induced hepatocarcinogenesis in male Fischer (F344) rats</title><author>Richmond, R.E. ; Carter, J.H. ; Carter, H.W. ; Daniel, F.B. ; DeAngelo, A.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-fdd9fd708860cb10c3a96e6ccacfe528894dad6639ae8e4960b358e4c19b68f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Aldehyde dehydrogenase</topic><topic>Aldehyde Dehydrogenase - analysis</topic><topic>Alpha fetoprotein</topic><topic>alpha-Fetoproteins - analysis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Cell Division</topic><topic>Chemical agents</topic><topic>Dichloroacetic acid</topic><topic>Dichloroacetic Acid - toxicity</topic><topic>Experimental hepatocarcinogenesis</topic><topic>Glutathione s-transferase</topic><topic>Glutathione Transferase - analysis</topic><topic>Immunoenzyme Techniques</topic><topic>Liver Neoplasms - chemically induced</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oncogene Protein p21(ras) - analysis</topic><topic>p21 ras</topic><topic>p39 c- jun</topic><topic>p55 c- fos</topic><topic>Proto-Oncogene Proteins c-fos - analysis</topic><topic>Proto-Oncogene Proteins c-jun - analysis</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Richmond, R.E.</creatorcontrib><creatorcontrib>Carter, J.H.</creatorcontrib><creatorcontrib>Carter, H.W.</creatorcontrib><creatorcontrib>Daniel, F.B.</creatorcontrib><creatorcontrib>DeAngelo, A.B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Richmond, R.E.</au><au>Carter, J.H.</au><au>Carter, H.W.</au><au>Daniel, F.B.</au><au>DeAngelo, A.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical analysis of dichloroacetic acid (DCA)-induced hepatocarcinogenesis in male Fischer (F344) rats</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1995-05-25</date><risdate>1995</risdate><volume>92</volume><issue>1</issue><spage>67</spage><epage>76</epage><pages>67-76</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>We examined the incidence of proliferative lesions, hyperplastic nodules and altered hepatic foci, in male F344 rat liver, to determine their preneoplastic potential during dichloroacetic acid (DCA)-induced hepatocarcinogenesis. Immunohistochemical and image analysis methods were used to detect the expression of 6 histochemical markers of neoplastic cells; p21
ras, p39 c-
jun, p55 c-
fos, aldehyde dehydrogenase (ALDH), glutathione s-transferase (GST-p), and alpha fetoprotein (AFP) during DCA-induced hepatocarcinogenesis. Our results were consistent with our previous data and suggested that the hyperplastic nodules, rather than altered hepatic foci, is a putative preneoplastic lesion during DCA-induced hepatocarcinogenesis in the male F344 rat.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>7538896</pmid><doi>10.1016/0304-3835(94)03756-9</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Cancer letters, 1995-05, Vol.92 (1), p.67-76 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16854346 |
| source | ScienceDirect Freedom Collection |
| subjects | Aldehyde dehydrogenase Aldehyde Dehydrogenase - analysis Alpha fetoprotein alpha-Fetoproteins - analysis Animals Biological and medical sciences Biomarkers, Tumor - analysis Carcinogenesis, carcinogens and anticarcinogens Cell Division Chemical agents Dichloroacetic acid Dichloroacetic Acid - toxicity Experimental hepatocarcinogenesis Glutathione s-transferase Glutathione Transferase - analysis Immunoenzyme Techniques Liver Neoplasms - chemically induced Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Medical sciences Oncogene Protein p21(ras) - analysis p21 ras p39 c- jun p55 c- fos Proto-Oncogene Proteins c-fos - analysis Proto-Oncogene Proteins c-jun - analysis Rats Rats, Inbred F344 Tumors |
| title | Immunohistochemical analysis of dichloroacetic acid (DCA)-induced hepatocarcinogenesis in male Fischer (F344) rats |
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