Target organ damage and control of cardiovascular risk factors in hypertensive patients: Evidence from the multicenter ESTher registry

Aims This study investigated the incidence of hypertensive target organ damage (TOD), control of cardiovascular risk factors, and the short-term prognosis in hypertensive patients under contemporary guideline-oriented therapy. Patients and methods A total of 1,377 consecutive patients (mean age 58.2...

Full description

Saved in:
Bibliographic Details
Published in:Herz 2015-04, Vol.40 (Suppl 2), p.209-216
Main Authors: Reibis, R.K., Huber, M., Karoff, M., Kamke, W., Kreutz, R., Wegscheider, K., Völler, H.
Format: Article
Language:English
Subjects:
Cardiology
Comorbidity
Evidence-Based Medicine
Female
Germany - epidemiology
Humans
Hypertension - mortality
Hypertrophy, Left Ventricular - mortality
Incidence
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Organs at Risk
Original Article
Registries
Renal Insufficiency - mortality
Risk Factors
Survival Rate
Ventricular Dysfunction, Left - mortality
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims This study investigated the incidence of hypertensive target organ damage (TOD), control of cardiovascular risk factors, and the short-term prognosis in hypertensive patients under contemporary guideline-oriented therapy. Patients and methods A total of 1,377 consecutive patients (mean age 58.2 ± 9.9 years, 82.2 % male) with arterial hypertension were included in the ESTher ( Endorganschäden, Therapie und Verlauf – target organ damage, therapy, and course) registry at 15 rehabilitation clinics within the framework of the National Genome Research Network. Cardiovascular risk factors, medication, comorbidities, and glomerular filtration rate (GFR) were assessed. Left ventricular hypertrophy (LVH), left ventricular mass (LVM), left ventricular mass index (LVMI), and left ventricular ejection fraction (LVEF) were determined by two-dimensional echocardiography. The mean follow-up was 513 ± 159 days. Changes in continuous parameters were tested by the t test, changes in discrete characteristics are presented by means of transition tables and tested with the McNemar test. Results The mean LVEF was 59.3 ± 9.9 %, both mean LVM (238.6 ± 101.5 g) and LVMI (54.0 ± 23.6 g/m 2.7 ) were increased while relative wall thickness (RWT, 0.46 ± 0.18) indicated the presence of concentric LVH. Of the patients, 10.2 % displayed renal dysfunction (estimated GFR
ISSN:0340-9937
1615-6692
DOI:10.1007/s00059-014-4189-8