Drug-induced liver injury from initial dose of infliximab

Acute hepatotoxicity secondary to infliximab can occur with or without autoimmunity. A growing body of infliximab drug-induced liver injury cases without autoantibody formation is emerging. Nearly all other reported cases occur after at least three doses. This suggests infliximab may have a direct c...

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Bibliographic Details
Published in:Military medicine 2015-06, Vol.180 (6), p.e723-e724
Main Authors: Cheng, Fong-Kuei F, Bridges, Edward E, Betteridge, John D
Format: Article
Language:English
Subjects:
Adult
Chemical and Drug Induced Liver Injury - etiology
Colitis, Ulcerative - drug therapy
Gastrointestinal Agents - adverse effects
Humans
Infliximab - adverse effects
Male
Military Personnel
United States
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Summary:Acute hepatotoxicity secondary to infliximab can occur with or without autoimmunity. A growing body of infliximab drug-induced liver injury cases without autoantibody formation is emerging. Nearly all other reported cases occur after at least three doses. This suggests infliximab may have a direct cytotoxic effect on the liver. We report a case of drug-induced liver injury resulting after an initial dose of infliximab.
ISSN:0026-4075
1930-613X
DOI:10.7205/MILMED-D-14-00485