Macrophages and cancer: from mechanisms to therapeutic implications

Highlights • Circulating monocytes are the primary source of TAMs in many tumors. • TAM properties are shaped by tissue- and tumor-specific microenvironmental signals. • The ensuing TAM heterogeneity is not captured by the classical M1/M2 nomenclature. • TAM depletion or reconditioning has therapeut...

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Bibliographic Details
Published in:Trends in immunology 2015-04, Vol.36 (4), p.229-239
Main Authors: Ostuni, Renato, Kratochvill, Franz, Murray, Peter J, Natoli, Gioacchino
Format: Article
Language:English
Subjects:
Acquisitions & mergers
Allergy and Immunology
Cancer
Chemotherapy
Cytokines
Cytotoxicity
Gene expression
Humans
Immune system
Lymphocytes
Macrophages - immunology
Metastasis
Neoplasms - immunology
Neoplasms - pathology
Neoplasms - therapy
Stem cells
Tumor Microenvironment - drug effects
Tumorigenesis
Tumors
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Summary:Highlights • Circulating monocytes are the primary source of TAMs in many tumors. • TAM properties are shaped by tissue- and tumor-specific microenvironmental signals. • The ensuing TAM heterogeneity is not captured by the classical M1/M2 nomenclature. • TAM depletion or reconditioning has therapeutic relevance in specific tumors.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2015.02.004