Determination of ethyl carbamate in fermented liquids by ultra high performance liquid chromatography coupled with a Q Exactive hybrid quadrupole-orbitrap mass spectrometer

•An UHPLC–MS/MS method was firstly established for EC detection in fermented liquids.•The method was fully validated.•The method was simple in sample preparation and fast for EC determination.•The method could be a good alternative for EC determination in fermented liquids. In this study, the determ...

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Bibliographic Details
Published in:Food chemistry 2015-06, Vol.177, p.66-71
Main Authors: Zhao, Xirong, Jiang, Changxing
Format: Article
Language:English
Subjects:
Bioreactors
Chromatography, High Pressure Liquid - methods
Ethyl carbamate
Fermented liquid
Foods
High performance liquid chromatography
Joining
Liquids
Mass spectrometers
Q Exactive hybrid quadrupole-orbitrap mass spectrometer
Standard deviation
Tandem Mass Spectrometry - methods
Ultra high performance liquid chromatography
Urethane - analysis
Wine - analysis
Wines
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Summary:•An UHPLC–MS/MS method was firstly established for EC detection in fermented liquids.•The method was fully validated.•The method was simple in sample preparation and fast for EC determination.•The method could be a good alternative for EC determination in fermented liquids. In this study, the determination of ethyl carbamate (EC) in fermented liquids (red wines, Chinese liquors and yellow wines) was carried by using ultra high performance liquid chromatography coupled with a Q Exactive hybrid quadrupole-orbitrap mass spectrometer (UHPLC–MS/MS). The parameters usually examined in the method validation were firstly evaluated. Good linearity was obtained with a correlation coefficient of 0.9999. The limits of detection (LOD) and quantitation (LOQ) of EC in sample were 1.8 and 4.0μg/L, respectively. Recoveries ranged between 107.19% and 110.98%. The precision (relative standard deviation, RSD) of the method was
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2015.01.025