Inhibiting EGFR Clustering and Cell Proliferation with Gold Nanoparticles

Gold nanoparticles are functionalized with epidermal growth factor (EGF) molecules and incubated with HeLa cells. These new complexes mechanically interfere with the activation of EGF receptors in a length‐dependent manner. Protein‐functionalized gold nanoparticles hold great potential for unveiling...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2015-04, Vol.11 (14), p.1638-1643
Main Authors: Paviolo, Chiara, Chon, James W. M., Clayton, Andrew H. A.
Format: Article
Language:English
Subjects:
Activation
Cell Proliferation
Clustering
epidermal growth factor
epidermal growth factor receptor
Gold
Gold - chemistry
gold nanoparticles
Growth factors
HeLa Cells
Humans
Metal Nanoparticles
Nanoparticles
Nanotechnology
Receptor, Epidermal Growth Factor - antagonists & inhibitors
Receptor, Epidermal Growth Factor - metabolism
Receptors
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Summary:Gold nanoparticles are functionalized with epidermal growth factor (EGF) molecules and incubated with HeLa cells. These new complexes mechanically interfere with the activation of EGF receptors in a length‐dependent manner. Protein‐functionalized gold nanoparticles hold great potential for unveiling the fundamental characteristics of cell receptors and for future pharmacological studies on receptor targeting.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201402701