Monofluoromethylation of Tetrahydroisoquinolines by Visible-light Induced Direct C(sp3)H Bond Activation

A visible‐light photoredox‐catalyzed reaction of tetrahydroisoquinolines with β‐fluorinated gem‐diols results in the formation of C1‐monofluoromethylated tetrahydroisoquinolines via C(sp3)H bond activation. This protocol provides a new method to introduce a CF group with stable, easily‐prepared mon...

Full description

Saved in:
Bibliographic Details
Published in:Advanced synthesis & catalysis 2015-04, Vol.357 (6), p.1277-1282
Main Authors: Li, Weipeng, Zhu, Yunhuang, Duan, Yingqian, Zhang, Muliang, Zhu, Chengjian
Format: Article
Language:English
Subjects:
Activation
Bonding
C(sp3)H activation
Catalysis
Formations
monofluoromethylation
photoredox catalytic
Synthesis
tetrahydroisoquinolines
visible light
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A visible‐light photoredox‐catalyzed reaction of tetrahydroisoquinolines with β‐fluorinated gem‐diols results in the formation of C1‐monofluoromethylated tetrahydroisoquinolines via C(sp3)H bond activation. This protocol provides a new method to introduce a CF group with stable, easily‐prepared monofluorinated gem‐diol as CF source. A mechanistic investigation is presented based on control experiments.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201401146