Structure related transport properties and cellular uptake of hyperbranched polyglycerol sulfates with hydrophobic cores

A set of six hydrophobically derivatized polymers based on polyglycerol sulfates have been investigated to determine the influence of scaffold architecture on the encapsulation properties of hydrophobic guests. Each of three block and statistical copolymers has been synthesized with phenyl, naphthyl...

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Bibliographic Details
Published in:Polymer chemistry 2014-09, Vol.5 (17), p.5020-5028
Main Authors: Paulus, Florian, Steinhilber, Dirk, Welker, Pia, Mangoldt, Dorothea, Licha, Kai, Depner, Harald, Sigrist, Stephan, Haag, Rainer
Format: Article
Language:English
Subjects:
Architecture
Cellular
Cellular structure
Encapsulation
Polyglycerols
Sulfates
Transport properties
Uptakes
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Summary:A set of six hydrophobically derivatized polymers based on polyglycerol sulfates have been investigated to determine the influence of scaffold architecture on the encapsulation properties of hydrophobic guests. Each of three block and statistical copolymers has been synthesized with phenyl, naphthyl, and biphenyl substituents in a one-pot procedure. The copolymers have been functionalized with sulfate groups in order to introduce an electrostatically repulsive surface that can stabilize the aggregated carriers. In addition, sulfates provide a highly active targeting moiety for inflammation and cellular uptake. UV measurements show a supramolecular encapsulation of the investigated guest molecules in the low mu M range. The transport studies with pyrene and an indocarbocyanine dye further indicated a core-shell-type architecture which provides a distinct amphiphilicity as required for supramolecular guest complexation. The combination of a host functionality with an active sulfate targeting moiety has been used to investigate the structure related cellular transport properties.
ISSN:1759-9954
1759-9962
DOI:10.1039/C4PY00430B