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K-t GRAPPA-accelerated 4D flow MRI of liver hemodynamics: influence of different acceleration factors on qualitative and quantitative assessment of blood flow
Objective We sought to evaluate the feasibility of k-t parallel imaging for accelerated 4D flow MRI in the hepatic vascular system by investigating the impact of different acceleration factors. Materials and methods k-t GRAPPA accelerated 4D flow MRI of the liver vasculature was evaluated in 16 heal...
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| Published in: | Magma (New York, N.Y.) N.Y.), 2015-04, Vol.28 (2), p.149-159 |
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| creator | Stankovic, Zoran Fink, Jury Collins, Jeremy D. Semaan, Edouard Russe, Maximilian F. Carr, James C. Markl, Michael Langer, Mathias Jung, Bernd |
| description | Objective
We sought to evaluate the feasibility of k-t parallel imaging for accelerated 4D flow MRI in the hepatic vascular system by investigating the impact of different acceleration factors.
Materials and methods
k-t GRAPPA accelerated 4D flow MRI of the liver vasculature was evaluated in 16 healthy volunteers at 3T with acceleration factors
R
= 3,
R
= 5, and
R
= 8 (2.0 × 2.5 × 2.4 mm
3
, TR = 82 ms), and
R
= 5 (TR = 41 ms); GRAPPA
R
= 2 was used as the reference standard. Qualitative flow analysis included grading of 3D streamlines and time-resolved particle traces. Quantitative evaluation assessed velocities, net flow, and wall shear stress (WSS).
Results
Significant scan time savings were realized for all acceleration factors compared to standard GRAPPA
R
= 2 (21–71 %) (
p
|
| doi_str_mv | 10.1007/s10334-014-0456-1 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1685781981</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1680450744</sourcerecordid><originalsourceid>FETCH-LOGICAL-c593t-d81917947bb8860dd01ac0b7a7d7c902453b54fe92209dae7c2208cd1cfc341f3</originalsourceid><addsrcrecordid>eNqNkcFuFSEUhomxsdfqA7gxLN2gMMAwuLupWpu2sWl0TRg46DQz0MJMTV_GZ5Xx1rtsuiAcDt_5z4EfoTeMvmeUqg-FUc4FoawuIVvCnqEN47IhXduy52hDddsR2Qh-iF6Wck1pwyTlL9BhI6nWQvMN-nNGZnxytb283BLrHIyQ7Qwei084jOk3vrg6xSngcbiDjH_BlPx9tNPgykc8xDAuEB2sgB9CgAxxxnuVIUUcrJtTLriGt4sdh7mm7wDb6NdznPeJUqCUaa2vYv2Ykv_X_xU6CHYs8PphP0I_vnz-fvyVnH87OT3enhMnNZ-J75hmSgvV913XUu8ps472yiqvnKaNkLyXIoBuGqq9BeVq0DnPXHBcsMCP0Lud7k1OtwuU2UxDqe8YbYS0FMPaTqrapGNPQasZVAnxBFSxOpDivKJsh7qcSskQzE0eJpvvDaNmNdvszDbVbLOabdZJ3j7IL_0Efl_x390KNDug1Kv4E7K5TkuO9SMfUf0LqIq1gA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1671209733</pqid></control><display><type>article</type><title>K-t GRAPPA-accelerated 4D flow MRI of liver hemodynamics: influence of different acceleration factors on qualitative and quantitative assessment of blood flow</title><source>Springer Nature</source><creator>Stankovic, Zoran ; Fink, Jury ; Collins, Jeremy D. ; Semaan, Edouard ; Russe, Maximilian F. ; Carr, James C. ; Markl, Michael ; Langer, Mathias ; Jung, Bernd</creator><creatorcontrib>Stankovic, Zoran ; Fink, Jury ; Collins, Jeremy D. ; Semaan, Edouard ; Russe, Maximilian F. ; Carr, James C. ; Markl, Michael ; Langer, Mathias ; Jung, Bernd</creatorcontrib><description>Objective
We sought to evaluate the feasibility of k-t parallel imaging for accelerated 4D flow MRI in the hepatic vascular system by investigating the impact of different acceleration factors.
Materials and methods
k-t GRAPPA accelerated 4D flow MRI of the liver vasculature was evaluated in 16 healthy volunteers at 3T with acceleration factors
R
= 3,
R
= 5, and
R
= 8 (2.0 × 2.5 × 2.4 mm
3
, TR = 82 ms), and
R
= 5 (TR = 41 ms); GRAPPA
R
= 2 was used as the reference standard. Qualitative flow analysis included grading of 3D streamlines and time-resolved particle traces. Quantitative evaluation assessed velocities, net flow, and wall shear stress (WSS).
Results
Significant scan time savings were realized for all acceleration factors compared to standard GRAPPA
R
= 2 (21–71 %) (
p
< 0.001). Quantification of velocities and net flow offered similar results between k-t GRAPPA
R
= 3 and
R
= 5 compared to standard GRAPPA
R
= 2. Significantly increased leakage artifacts and noise were seen between standard GRAPPA
R
= 2 and k-t GRAPPA
R
= 8 (
p
< 0.001) with significant underestimation of peak velocities and WSS of up to 31 % in the hepatic arterial system (
p
<0.05). WSS was significantly underestimated up to 13 % in all vessels of the portal venous system for k-t GRAPPA
R
= 5, while significantly higher values were observed for the same acceleration with higher temporal resolution in two veins (
p
< 0.05).
Conclusion
k-t acceleration of 4D flow MRI is feasible for liver hemodynamic assessment with acceleration factors
R
= 3 and
R
= 5 resulting in a scan time reduction of at least 40 % with similar quantitation of liver hemodynamics compared with GRAPPA
R
= 2.</description><identifier>ISSN: 0968-5243</identifier><identifier>EISSN: 1352-8661</identifier><identifier>DOI: 10.1007/s10334-014-0456-1</identifier><identifier>PMID: 25099493</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acceleration ; Adult ; Assessments ; Biomedical Engineering and Bioengineering ; Blood Flow Velocity - physiology ; Computer Appl. in Life Sciences ; Feasibility Studies ; Female ; Health Informatics ; Hemodynamics ; Humans ; Image Enhancement - methods ; Image Interpretation, Computer-Assisted - methods ; Imaging ; Imaging, Three-Dimensional - methods ; Liver ; Liver - anatomy & histology ; Liver - physiology ; Liver Circulation - physiology ; Magnetic resonance ; Magnetic Resonance Angiography - methods ; Magnetic resonance imaging ; Medicine & Public Health ; Radiology ; Reproducibility of Results ; Research Article ; Respiratory-Gated Imaging Techniques - methods ; Sensitivity and Specificity ; Shear Strength - physiology ; Solid State Physics ; Three dimensional ; Veins</subject><ispartof>Magma (New York, N.Y.), 2015-04, Vol.28 (2), p.149-159</ispartof><rights>ESMRMB 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-d81917947bb8860dd01ac0b7a7d7c902453b54fe92209dae7c2208cd1cfc341f3</citedby><cites>FETCH-LOGICAL-c593t-d81917947bb8860dd01ac0b7a7d7c902453b54fe92209dae7c2208cd1cfc341f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25099493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stankovic, Zoran</creatorcontrib><creatorcontrib>Fink, Jury</creatorcontrib><creatorcontrib>Collins, Jeremy D.</creatorcontrib><creatorcontrib>Semaan, Edouard</creatorcontrib><creatorcontrib>Russe, Maximilian F.</creatorcontrib><creatorcontrib>Carr, James C.</creatorcontrib><creatorcontrib>Markl, Michael</creatorcontrib><creatorcontrib>Langer, Mathias</creatorcontrib><creatorcontrib>Jung, Bernd</creatorcontrib><title>K-t GRAPPA-accelerated 4D flow MRI of liver hemodynamics: influence of different acceleration factors on qualitative and quantitative assessment of blood flow</title><title>Magma (New York, N.Y.)</title><addtitle>Magn Reson Mater Phy</addtitle><addtitle>MAGMA</addtitle><description>Objective
We sought to evaluate the feasibility of k-t parallel imaging for accelerated 4D flow MRI in the hepatic vascular system by investigating the impact of different acceleration factors.
Materials and methods
k-t GRAPPA accelerated 4D flow MRI of the liver vasculature was evaluated in 16 healthy volunteers at 3T with acceleration factors
R
= 3,
R
= 5, and
R
= 8 (2.0 × 2.5 × 2.4 mm
3
, TR = 82 ms), and
R
= 5 (TR = 41 ms); GRAPPA
R
= 2 was used as the reference standard. Qualitative flow analysis included grading of 3D streamlines and time-resolved particle traces. Quantitative evaluation assessed velocities, net flow, and wall shear stress (WSS).
Results
Significant scan time savings were realized for all acceleration factors compared to standard GRAPPA
R
= 2 (21–71 %) (
p
< 0.001). Quantification of velocities and net flow offered similar results between k-t GRAPPA
R
= 3 and
R
= 5 compared to standard GRAPPA
R
= 2. Significantly increased leakage artifacts and noise were seen between standard GRAPPA
R
= 2 and k-t GRAPPA
R
= 8 (
p
< 0.001) with significant underestimation of peak velocities and WSS of up to 31 % in the hepatic arterial system (
p
<0.05). WSS was significantly underestimated up to 13 % in all vessels of the portal venous system for k-t GRAPPA
R
= 5, while significantly higher values were observed for the same acceleration with higher temporal resolution in two veins (
p
< 0.05).
Conclusion
k-t acceleration of 4D flow MRI is feasible for liver hemodynamic assessment with acceleration factors
R
= 3 and
R
= 5 resulting in a scan time reduction of at least 40 % with similar quantitation of liver hemodynamics compared with GRAPPA
R
= 2.</description><subject>Acceleration</subject><subject>Adult</subject><subject>Assessments</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Blood Flow Velocity - physiology</subject><subject>Computer Appl. in Life Sciences</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Health Informatics</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Imaging</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Liver</subject><subject>Liver - anatomy & histology</subject><subject>Liver - physiology</subject><subject>Liver Circulation - physiology</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Angiography - methods</subject><subject>Magnetic resonance imaging</subject><subject>Medicine & Public Health</subject><subject>Radiology</subject><subject>Reproducibility of Results</subject><subject>Research Article</subject><subject>Respiratory-Gated Imaging Techniques - methods</subject><subject>Sensitivity and Specificity</subject><subject>Shear Strength - physiology</subject><subject>Solid State Physics</subject><subject>Three dimensional</subject><subject>Veins</subject><issn>0968-5243</issn><issn>1352-8661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNkcFuFSEUhomxsdfqA7gxLN2gMMAwuLupWpu2sWl0TRg46DQz0MJMTV_GZ5Xx1rtsuiAcDt_5z4EfoTeMvmeUqg-FUc4FoawuIVvCnqEN47IhXduy52hDddsR2Qh-iF6Wck1pwyTlL9BhI6nWQvMN-nNGZnxytb283BLrHIyQ7Qwei084jOk3vrg6xSngcbiDjH_BlPx9tNPgykc8xDAuEB2sgB9CgAxxxnuVIUUcrJtTLriGt4sdh7mm7wDb6NdznPeJUqCUaa2vYv2Ykv_X_xU6CHYs8PphP0I_vnz-fvyVnH87OT3enhMnNZ-J75hmSgvV913XUu8ps472yiqvnKaNkLyXIoBuGqq9BeVq0DnPXHBcsMCP0Lud7k1OtwuU2UxDqe8YbYS0FMPaTqrapGNPQasZVAnxBFSxOpDivKJsh7qcSskQzE0eJpvvDaNmNdvszDbVbLOabdZJ3j7IL_0Efl_x390KNDug1Kv4E7K5TkuO9SMfUf0LqIq1gA</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Stankovic, Zoran</creator><creator>Fink, Jury</creator><creator>Collins, Jeremy D.</creator><creator>Semaan, Edouard</creator><creator>Russe, Maximilian F.</creator><creator>Carr, James C.</creator><creator>Markl, Michael</creator><creator>Langer, Mathias</creator><creator>Jung, Bernd</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SC</scope><scope>7U5</scope><scope>JQ2</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope></search><sort><creationdate>20150401</creationdate><title>K-t GRAPPA-accelerated 4D flow MRI of liver hemodynamics: influence of different acceleration factors on qualitative and quantitative assessment of blood flow</title><author>Stankovic, Zoran ; Fink, Jury ; Collins, Jeremy D. ; Semaan, Edouard ; Russe, Maximilian F. ; Carr, James C. ; Markl, Michael ; Langer, Mathias ; Jung, Bernd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-d81917947bb8860dd01ac0b7a7d7c902453b54fe92209dae7c2208cd1cfc341f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acceleration</topic><topic>Adult</topic><topic>Assessments</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Blood Flow Velocity - physiology</topic><topic>Computer Appl. in Life Sciences</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Health Informatics</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Imaging</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Liver</topic><topic>Liver - anatomy & histology</topic><topic>Liver - physiology</topic><topic>Liver Circulation - physiology</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Angiography - methods</topic><topic>Magnetic resonance imaging</topic><topic>Medicine & Public Health</topic><topic>Radiology</topic><topic>Reproducibility of Results</topic><topic>Research Article</topic><topic>Respiratory-Gated Imaging Techniques - methods</topic><topic>Sensitivity and Specificity</topic><topic>Shear Strength - physiology</topic><topic>Solid State Physics</topic><topic>Three dimensional</topic><topic>Veins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stankovic, Zoran</creatorcontrib><creatorcontrib>Fink, Jury</creatorcontrib><creatorcontrib>Collins, Jeremy D.</creatorcontrib><creatorcontrib>Semaan, Edouard</creatorcontrib><creatorcontrib>Russe, Maximilian F.</creatorcontrib><creatorcontrib>Carr, James C.</creatorcontrib><creatorcontrib>Markl, Michael</creatorcontrib><creatorcontrib>Langer, Mathias</creatorcontrib><creatorcontrib>Jung, Bernd</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><jtitle>Magma (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stankovic, Zoran</au><au>Fink, Jury</au><au>Collins, Jeremy D.</au><au>Semaan, Edouard</au><au>Russe, Maximilian F.</au><au>Carr, James C.</au><au>Markl, Michael</au><au>Langer, Mathias</au><au>Jung, Bernd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>K-t GRAPPA-accelerated 4D flow MRI of liver hemodynamics: influence of different acceleration factors on qualitative and quantitative assessment of blood flow</atitle><jtitle>Magma (New York, N.Y.)</jtitle><stitle>Magn Reson Mater Phy</stitle><addtitle>MAGMA</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>28</volume><issue>2</issue><spage>149</spage><epage>159</epage><pages>149-159</pages><issn>0968-5243</issn><eissn>1352-8661</eissn><abstract>Objective
We sought to evaluate the feasibility of k-t parallel imaging for accelerated 4D flow MRI in the hepatic vascular system by investigating the impact of different acceleration factors.
Materials and methods
k-t GRAPPA accelerated 4D flow MRI of the liver vasculature was evaluated in 16 healthy volunteers at 3T with acceleration factors
R
= 3,
R
= 5, and
R
= 8 (2.0 × 2.5 × 2.4 mm
3
, TR = 82 ms), and
R
= 5 (TR = 41 ms); GRAPPA
R
= 2 was used as the reference standard. Qualitative flow analysis included grading of 3D streamlines and time-resolved particle traces. Quantitative evaluation assessed velocities, net flow, and wall shear stress (WSS).
Results
Significant scan time savings were realized for all acceleration factors compared to standard GRAPPA
R
= 2 (21–71 %) (
p
< 0.001). Quantification of velocities and net flow offered similar results between k-t GRAPPA
R
= 3 and
R
= 5 compared to standard GRAPPA
R
= 2. Significantly increased leakage artifacts and noise were seen between standard GRAPPA
R
= 2 and k-t GRAPPA
R
= 8 (
p
< 0.001) with significant underestimation of peak velocities and WSS of up to 31 % in the hepatic arterial system (
p
<0.05). WSS was significantly underestimated up to 13 % in all vessels of the portal venous system for k-t GRAPPA
R
= 5, while significantly higher values were observed for the same acceleration with higher temporal resolution in two veins (
p
< 0.05).
Conclusion
k-t acceleration of 4D flow MRI is feasible for liver hemodynamic assessment with acceleration factors
R
= 3 and
R
= 5 resulting in a scan time reduction of at least 40 % with similar quantitation of liver hemodynamics compared with GRAPPA
R
= 2.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25099493</pmid><doi>10.1007/s10334-014-0456-1</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0968-5243 |
| ispartof | Magma (New York, N.Y.), 2015-04, Vol.28 (2), p.149-159 |
| issn | 0968-5243 1352-8661 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1685781981 |
| source | Springer Nature |
| subjects | Acceleration Adult Assessments Biomedical Engineering and Bioengineering Blood Flow Velocity - physiology Computer Appl. in Life Sciences Feasibility Studies Female Health Informatics Hemodynamics Humans Image Enhancement - methods Image Interpretation, Computer-Assisted - methods Imaging Imaging, Three-Dimensional - methods Liver Liver - anatomy & histology Liver - physiology Liver Circulation - physiology Magnetic resonance Magnetic Resonance Angiography - methods Magnetic resonance imaging Medicine & Public Health Radiology Reproducibility of Results Research Article Respiratory-Gated Imaging Techniques - methods Sensitivity and Specificity Shear Strength - physiology Solid State Physics Three dimensional Veins |
| title | K-t GRAPPA-accelerated 4D flow MRI of liver hemodynamics: influence of different acceleration factors on qualitative and quantitative assessment of blood flow |
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