Dietary exposure to phenolic and methoxylated organohalogen contaminants in relation to their concentrations in breast milk and serum in Japan

This study investigated human exposure to neutral, phenolic, and methoxylated organohalogen contaminants (OHCs) in a duplicate diet study to evaluate their concentrations in breast milk and serum of Okinawan people from Japan during 2004-2009. Dietary intakes of phenolic OHCs were predominantly 2,4,...

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Bibliographic Details
Published in:Environment international 2014-02, Vol.63, p.19-25
Main Authors: FUJII, Yukiko, NISHIMURA, Eri, KATO, Yoshihisa, HARADA, Kouji H, KOIZUMI, Akio, HARAGUCHI, Koichi
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Breast
Contaminants
Diet
Diets
Environment. Living conditions
Environmental pollutants toxicology
Ethers
Exposure
Female
Food Contamination
Halogenated Diphenyl Ethers - analysis
Halogenated Diphenyl Ethers - blood
Humans
Intakes
Japan
Medical sciences
Milk
Milk, Human - chemistry
Organohalogens
Phenols - analysis
Phenols - blood
Polybrominated Biphenyls - analysis
Polybrominated Biphenyls - blood
Public health. Hygiene
Public health. Hygiene-occupational medicine
Serums
Toxicology
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Summary:This study investigated human exposure to neutral, phenolic, and methoxylated organohalogen contaminants (OHCs) in a duplicate diet study to evaluate their concentrations in breast milk and serum of Okinawan people from Japan during 2004-2009. Dietary intakes of phenolic OHCs were predominantly 2,4,6-tribromophenol (TriBP), followed by tetrabromobisphenol A (TBBPA), and 6-hydroxy-2,2',4,4'-tetrabromodiphenyl ether (6-OH-BDE47). After exposure, TriBP and TBBPA were transferred to breast milk, whereas 6-OH-BDE47 was selectively retained in serum. Despite a lower dietary exposure to pentachlorophenol and 4-hydroxy-CB187, both were retained in serum. For the methoxylated OHCs, 2,4,6-tribromoanisole (TriBA) and 6-methoxy-BDE47 were the predominant dietary contaminants, of which TriBA was present in both breast milk and serum, whereas 6-methoxy-BDE47 was selectively transferred to breast milk. These findings suggest that dietary exposure to phenolic and methoxylated OHCs may result in differential partitioning between breast milk and serum with different pharmacokinetic or exposure routes.
ISSN:0160-4120
1873-6750
DOI:10.1016/j.envint.2013.10.016