Folic acid-polyamine-β-cyclodextrin for targeted delivery of scutellarin to cancer cells

The efficient tumor targeting drug carrier was designed by bioconjugation of folic acid to β‐cyclodextrin through a polyamine cationic spacer. The characterization and inclusion complexation behavior of the inclusion complex of hydrophobic drug scutellarin with folic acid‐polyamine‐β‐cyclodextrin we...

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Bibliographic Details
Published in:Polymers for advanced technologies 2015-05, Vol.26 (5), p.487-494
Main Authors: Liao, Rongqiang, Zhao, Yulin, Liao, Xiali, Liu, Manshuo, Gao, Chuanzhu, Yang, Jian, Yang, Bo
Format: Article
Language:English
Subjects:
Carriers
Cationic
Complexation
cyclodextrin
Diffraction
Drugs
folic acid
inclusion complex
Inclusion complexes
Inclusions
Solubilization
Spacers
targeting
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Summary:The efficient tumor targeting drug carrier was designed by bioconjugation of folic acid to β‐cyclodextrin through a polyamine cationic spacer. The characterization and inclusion complexation behavior of the inclusion complex of hydrophobic drug scutellarin with folic acid‐polyamine‐β‐cyclodextrin were investigated in both solution and solid state by means of phase‐solubility, nuclear magnetic resonance, X‐ray power diffraction, thermal gravimetric analysis, and scanning electron microscopy. Besides, the solubilization efficiency and antitumor activity of the inclusion complex were tested by saturated solution and MTT (Thiazole blue) method. Solubility and antitumor activity studies showed higher solubilizing ability and antitumor activity of the inclusion complex in comparison to free scutellarin. The folic acid‐polyamine‐β‐cyclodextrin that is presented may be promising active tumor‐targeting carrier candidates via folate mediation. Copyright © 2015 John Wiley & Sons, Ltd.
ISSN:1042-7147
1099-1581
DOI:10.1002/pat.3477