Lysine, Arginine, and Histidine Residues in Peptide-Catalyzed Hydrogen Evolution at Mercury Electrodes

Involvement of hexapeptides composed of lysine (Lys6), arginine (Arg6) or histidine (His6) in the catalytic hydrogen evolution reaction (CHER) was studied. Using McIlvaine buffer, we changed the concentration of citric acid (proton donor in the CHER) either (a) by changing the buffer concentration a...

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Bibliographic Details
Published in:Electroanalysis (New York, N.Y.) N.Y.), 2015-04, Vol.27 (4), p.910-916
Main Authors: Dorcak, Vlastimil, Vargova, Veronika, Ostatna, Veronika, Palecek, Emil
Format: Article
Language:English
Subjects:
Buffers
Catalysis
Catalytic hydrogen evolution
Chronopotentiometric stripping
Constants
Hexapeptide
Histidine
Hydrogen evolution
Lysine
Mercury electrodes
Protonation state
Residues
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Summary:Involvement of hexapeptides composed of lysine (Lys6), arginine (Arg6) or histidine (His6) in the catalytic hydrogen evolution reaction (CHER) was studied. Using McIlvaine buffer, we changed the concentration of citric acid (proton donor in the CHER) either (a) by changing the buffer concentration at constant pH or (b) by changing the pH at constant buffer concentration. These two approaches showed almost the same catalytic behavior of Lys6 and Arg6 but strikingly different ones in the case of His6. The results suggested that at neutral pH His residue is much weaker catalyzer than those of Lys or Arg.
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.201400644