Nitric oxide releasing plasma polymer coating with bacteriostatic properties and no cytotoxic side effects

We report a stable plasma polymer coating, using isopentyl nitrite as a volatile precursor, which releases nitric oxide at bacteriostatic concentrations when contacted with water, inhibiting bacterial growth without cytotoxic side effects to human mesenchymal stem/stromal cells.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-04, Vol.51 (32), p.7058-7060
Main Authors: Michl, Thomas D, Coad, Bryan R, Doran, Michael, Osiecki, Michael, Kafshgari, Morteza Hasanzadeh, Voelcker, Nicolas H, Hüsler, Amanda, Vasilev, Krasimir, Griesser, Hans J
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Bacteria
Coating
Drug Carriers - chemistry
Drug Liberation
Human
Humans
Nitric oxide
Nitric Oxide - chemistry
Nitrites
Plasma Gases - chemistry
Polymers - adverse effects
Polymers - chemistry
Polymers - pharmacology
Precursors
Releasing
Side effects
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Description
Summary:We report a stable plasma polymer coating, using isopentyl nitrite as a volatile precursor, which releases nitric oxide at bacteriostatic concentrations when contacted with water, inhibiting bacterial growth without cytotoxic side effects to human mesenchymal stem/stromal cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc01722j