Prediction of the bioconcentration factor in common carp (Cyprinus carpio L.) using data from the dietary exposure bioaccumulation fish test

• Published in: Environmental toxicology and chemistry 2014-06, Vol.33 (6), p.1406-1414
• Main Authors: Hashizume, Naoki, Tanabe, Aiko, Inoue, Yoshiyuki, Sawada, Takashi, Murakami, Hidekazu, Suzuki, Yasuyuki, Sumi, Shinichiro, Tsubokura, Yasuhiro, Yoshida, Tomohiko, Ajimi, Shozo, Tsuji, Toshiaki, Furukawa, Kotaro
• Format: Article
• Language: English
• Subjects: Agnatha. Pisces; Animal, plant and microbial ecology; Animals; Applied ecology; Bioaccumulation; bioaccumulation factor; Bioconcentration; Biological and medical sciences; Biological magnification; Biomagnification; Carp; Carps - metabolism; chemical substances; Chemicals; Classification; Common carp; correlation; Correlation coefficient; Cyprinus carpio; Databases, Chemical; Diet - adverse effects; dietary exposure; Economics; Ecotoxicology - methods; Ecotoxicology, biological effects of pollution; Effects of pollution and side effects of pesticides on vertebrates; Endpoint Determination; Environmental Pollutants - metabolism; Fish; Fish and seafood industries; Food industries; Fundamental and applied biological sciences. Psychology; Guidelines; Guidelines as Topic; Japan; Kinetics; Mathematical analysis; Models, Biological; OECD test guideline 305; prediction; Rate constants; Social Control, Formal; Toxicology; Uptakes
• ISSN: 0730-7268; 1552-8618
• DOI: 10.1002/etc.2572

An approach to predicting the bioconcentration factor (BCFₚᵣₑ) from the predicted uptake rate constant (k₁ ₚᵣₑ) and the depuration rate constant measured in the dietary exposure bioaccumulation fish test (k₂ dᵢₑₜₐᵣy) [BCFₚᵣₑ = k₁ ₚᵣₑ/k₂ dᵢₑₜₐᵣy] is proposed in test guideline 305 of the Organization for Economic Cooperation and Development Guidelines for Testing of Chemicals. Data were collected on the BCFs of 197 test chemicals from Japan's Chemical Substances Control Law database. To demonstrate how the BCFₚᵣₑ compares with experimentally derived BCF under optimum conditions, 48 of 197 test chemicals, including a number of studies that could be considered problematic, were excluded from the analysis. The k₁ ₚᵣₑ was calculated by using 22 published prediction methods: the correlations between experimental uptake rate constants (k₁ ₐqᵤₑₒᵤₛ) and k₁ ₚᵣₑ for all prediction methods were very low and were statistically nonsignificant (p > 0.05). Three prediction methods were also selected that gave relatively good values for the geometric mean of k₁ ₚᵣₑ/k₁ ₐqᵤₑₒᵤₛ and calculated values of BCFₚᵣₑ for 12 test chemicals. Linear relationships (p