Antibodies to Hmg Proteins in Patients with Drug‐Induced Autoimmunity

Objective. To determine the prevalence of auto‐antibodies to high‐mobility group (HMG) proteins in sera from patients with drug‐induced lupus (DIL). Methods. Forty‐two patients who developed auto‐antibodies and/or lupus after treatment with procainamide or other drugs were tested for HMG autoantibod...

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Bibliographic Details
Published in:Arthritis and rheumatism 1994-01, Vol.37 (1), p.98-103
Main Authors: Ayer, Linda M., Rubin, Robert L., Dixon, Gordon H., Fritzler, Marvin J.
Format: Article
Language:English
Subjects:
Acebutolol - therapeutic use
Autoantibodies - blood
Autoimmune Diseases - blood
Autoimmune Diseases - chemically induced
Autoimmunity - immunology
Biological and medical sciences
Enzyme-Linked Immunosorbent Assay
High Mobility Group Proteins - immunology
Humans
Immunoblotting
Immunomodulators
Lupus Vulgaris - blood
Lupus Vulgaris - chemically induced
Lupus Vulgaris - drug therapy
Medical sciences
Pharmacology. Drug treatments
Procainamide - adverse effects
Sulfasalazine - therapeutic use
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Summary:Objective. To determine the prevalence of auto‐antibodies to high‐mobility group (HMG) proteins in sera from patients with drug‐induced lupus (DIL). Methods. Forty‐two patients who developed auto‐antibodies and/or lupus after treatment with procainamide or other drugs were tested for HMG autoantibodies by immunoblotting and enzyme‐linked immunosorbent assay (ELISA). Results. Twenty‐eight of the 42 sera (67%) bound HMG‐14 and/or HMG‐17. In comparison, 9 of 42 (21%) bound HMG‐1 and/or HMG‐2. There was a good correlation between ELISA results and binding on immunoblots. Conclusion. The high prevalence of antibodies to the nucleosomal core HMGs (HMG‐14 and HMG‐17) in DIL patients adds evidence implicating nucleosomes as immunogens in drug‐induced autoimmunity.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780370115