Level of plasma thioredoxin in male patients with manic episode at initial and post‐electroconvulsive or antipsychotic treatment

Aim Oxidative stress is defined as exposure to excessive oxidants and/or decrease in antioxidant capacity. Several studies have shown the effects of free radicals and antioxidant defense systems in bipolar disorder. We aimed to investigate the role of thioredoxin (TRX), which is a novel oxidative st...

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Published in:Psychiatry and clinical neurosciences 2015-06, Vol.69 (6), p.344-350
Main Authors: Genc, Abdullah, Kalelioglu, Tevfik, Karamustafalioglu, Nesrin, Tasdemir, Akif, Gungor, Ferda Can, Genc, Esra Sena, Incir, Said, Ilnem, Cem, Emul, Murat
Format: Article
Language:English
Subjects:
Adult
Antioxidants
Antipsychotic Agents - therapeutic use
Bipolar disorder
Bipolar Disorder - blood
Bipolar Disorder - therapy
Case-Control Studies
Combined Modality Therapy
Electroconvulsive Therapy
Free radicals
Haloperidol - therapeutic use
Humans
Male
mania
Middle Aged
Oxidative Stress
Plasma
Psychiatry
Psychotropic drugs
Quetiapine Fumarate - therapeutic use
thioredoxin
Thioredoxins - blood
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Summary:Aim Oxidative stress is defined as exposure to excessive oxidants and/or decrease in antioxidant capacity. Several studies have shown the effects of free radicals and antioxidant defense systems in bipolar disorder. We aimed to investigate the role of thioredoxin (TRX), which is a novel oxidative stress marker in patients with bipolar disorder. Methods Sixty‐eight hospitalized bipolar patients who were in manic episode were included in the study. As a control group, 30 healthy people were elected. Two groups were formed. The first group consisted of patients who were undergoing electroconvulsive treatment + antipsychotic treatment (haloperidol+quetiapine) and members of the other group were taking only antipsychotic treatment. Plasma thioredoxin levels were measured before and after treatment. Results Pretreatment plasma TRX levels of patients were significantly lower than the controls (P  0.05) we did not find any statistically significant difference. Conclusion Oxidative balance is impaired in bipolar disorder manic episode in favor of the oxidants. Decreased plasma TRX levels in the manic episode probably mean that antioxidant capacity is decreased in the bipolar disorder patients in the manic episode. Further studies in euthymic and depressive states are also needed to gain more insight into the role of TRX in bipolar disorder.
ISSN:1323-1316
1440-1819
DOI:10.1111/pcn.12244