Retention of styrene following controlled exposure to constant and fluctuating air concentrations

• Published in: International archives of occupational and environmental health 1995-03, Vol.67 (1), p.27-34
• Main Authors: PETREAS, M. X, WOODLEE, J, BECKER, C. E, RAPPAPORT, S. M
• Format: Article
• Language: English
• Subjects: Adult; Air Pollutants - metabolism; Air Pollutants - pharmacokinetics; Analysis of Variance; Atmosphere Exposure Chambers; Biological and medical sciences; Chemical and industrial products toxicology. Toxic occupational diseases; Female; Humans; Male; Medical sciences; Models, Theoretical; Occupational Exposure; Respiration; Styrene; Styrenes - metabolism; Styrenes - pharmacokinetics; Toxicology; Various organic compounds
• ISSN: 0340-0131; 1432-1246
• DOI: 10.1007/BF00383129

An experiment was designed to determine whether the respiratory retention of styrene vapor, as estimated from measurements of end-exhaled air, was the same during periods of both constant and fluctuating exposure. Six human subjects were exposed to styrene inside a experimental chamber. A computer-controlled system was used to generate time-varying air concentrations of styrene over 4-5h in both multistep sequences of constant exposure (four subjects exposed to 15-99 ppm of styrene in 100-min steps) and fluctuating patterns representative of occupational exposures (two subjects exposed to mean concentrations of styrene of 50 ppm). In the latter case, lognormally distributed exposures, which fit one of two first-order autoregressive models, were generated at intervals of 2.5 min. It was found that the concentration of styrene in end-exhaled air was reduced by about half if the subject inhaled one to three breaths of clean air prior to sampling. This suggests that significant amounts of styrene were desorbed from the lining of the lungs during the initial exhalation. The retention of styrene vapor during constant exposures was 0.935 and was independent of the level. During each of the two sets of fluctuating exposure the retention of styrene was also constant and was independent of both the variance and autocorrelation coefficient. However, the retention of styrene during the fluctuating exposure (estimates ranged from 0.957 to 0.973) was significantly higher than that observed during the constant exposures.