How to define, diagnose and treat poor responders? Responses from a worldwide survey of IVF clinics

Abstract Poor responders represent a significant percentage of couples treated in IVF units (10–24%), but the standard definition of poor responders remains uncertain and consequently optimal treatment options remain subjective and not evidence-based. In an attempt to provide uniformity on the defin...

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Bibliographic Details
Published in:Reproductive biomedicine online 2015-06, Vol.30 (6), p.581-592
Main Authors: Patrizio, Pasquale, Vaiarelli, Alberto, Levi Setti, Paolo E, Tobler, Kyle J, Shoham, Gon, Leong, Milton, Shoham, Zeev
Format: Article
Language:English
Subjects:
decreased ovarian function
Evidence-Based Medicine
Female
Fertilization in Vitro
Humans
Internationality
Internet
IVF
Male
management
Obstetrics and Gynecology
ovarian stimulation
poor responder
Pregnancy
Pregnancy Rate
survey
Surveys and Questionnaires
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Summary:Abstract Poor responders represent a significant percentage of couples treated in IVF units (10–24%), but the standard definition of poor responders remains uncertain and consequently optimal treatment options remain subjective and not evidence-based. In an attempt to provide uniformity on the definition, diagnosis and treatment of poor responders, a worldwide survey was conducted asking IVF professionals a set of questions on this complex topic. The survey was posted on www.IVF-worldwide.com , the largest and most comprehensive IVF-focused website for physicians and embryologists. A total of 196 centres replied, forming a panel of IVF units with a median of 400 cycles per year. The present study shows that the definition of poor responders is still subjective, and many practices do not use evidence-based treatment for this category of patients. Our hope is that by leveraging the great potential of the internet, future studies may provide immediate large-scale sampling to standardize both poor responder definition and treatment options.
ISSN:1472-6483
1472-6491
DOI:10.1016/j.rbmo.2015.03.002