Cognitive Correlates of Cerebral Vasoreactivity on Transcranial Doppler in Older Adults

Background This study was performed to explore the possible contributions of cerebral hemodynamic changes to the cognitive impairment in patients with Alzheimer's disease (AD). Methods A total of 194 participants were included: 52 controls, 75 patients with mild cognitive impairment (MCI), and...

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Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2015-06, Vol.24 (6), p.1262-1269
Main Authors: Shim, YongSoo, MD, PhD, Yoon, Bora, MD, PhD, Shim, Dong Suk, MD, Kim, Woojun, MD, PhD, An, Jae-Young, MD, PhD, Yang, Dong-Won, MD, PhD
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - physiopathology
Alzheimer Disease - psychology
Alzheimer's disease
Blood Flow Velocity - physiology
Brain - physiopathology
Cardiovascular
cerebral vasoreactivity
Cognition Disorders - diagnostic imaging
Cognition Disorders - physiopathology
Cognition Disorders - psychology
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Middle Cerebral Artery - diagnostic imaging
Middle Cerebral Artery - physiopathology
Neurology
Neuropsychological Tests
old adults
Transcranial Doppler
Ultrasonography, Doppler, Transcranial
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Summary:Background This study was performed to explore the possible contributions of cerebral hemodynamic changes to the cognitive impairment in patients with Alzheimer's disease (AD). Methods A total of 194 participants were included: 52 controls, 75 patients with mild cognitive impairment (MCI), and 67 patients with AD. Demographic characteristics, vascular risks, mini-mental state examination (MMSE), and clinical dementia rating (CDR) were assessed, and magnetic resonance imaging of the brain was performed to evaluate white matter hyperintensities (WMHs). Using transcranial Doppler (TCD) ultrasonography, cerebrovascular reactivity (CVR) was evaluated with a breath-holding test, in addition to the mean blood flow velocity (MFV), pulsatility index (PI), and resistance index (RI) of the middle cerebral artery. Results After adjusting for covariates such as age, education, WMH severity, and vascular risks, TCD parameters such as MFV, PI, and RI did not differ between the 3 groups. However, CVR was significantly reduced in the AD group (45.33 ± 11.49%), compared with the other groups (56.36 ± 14.65%, controls; 53.84 ± 15.47%, MCI group; P  
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2015.01.031