Regulation of Muscle Satellite Cell Function in Tissue Homeostasis and Aging

Age-related muscle decline is associated with functional impairment of satellite cells (SCs). Conflicting data suggest dysregulation of cell-extrinsic or -intrinsic factors can independently contribute to such impairment. Here, we emphasize the importance of identifying nodes that integrate these fa...

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Bibliographic Details
Published in:Cell stem cell 2015-06, Vol.16 (6), p.585-587
Main Authors: Sacco, Alessandra, Puri, Pier Lorenzo
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Cellular Senescence
Homeostasis
Humans
Regeneration
Satellite Cells, Skeletal Muscle - physiology
Signal Transduction
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Summary:Age-related muscle decline is associated with functional impairment of satellite cells (SCs). Conflicting data suggest dysregulation of cell-extrinsic or -intrinsic factors can independently contribute to such impairment. Here, we emphasize the importance of identifying nodes that integrate these factors into feed-forward circuits, which could provide targets for therapeutic intervention. Satellite cells generate and repair myofibers throughout the life of an organism, but their function declines with age. In this Forum, Sacco and Puri discuss how cell-intrinsic and -extrinsic factors are integrated to control rejuvenation of satellite cell function in aged animals.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2015.05.007