Association of Wnt-Inducible Signaling Pathway Protein 1 Genetic Polymorphisms With Lung Cancer Susceptibility and Platinum-Based Chemotherapy Response

Micro-Abstract Wnt-inducible signaling pathway protein 1 ( WISP1 ) polymorphisms were associated with multiple lung diseases, including lung cancer. Twenty-eight polymorphisms of WISP1 were selected and genotyped in 556 lung cancer patients and 254 healthy controls. We identified 4 polymorphisms rel...

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Bibliographic Details
Published in:Clinical lung cancer 2015-07, Vol.16 (4), p.298-304.e2
Main Authors: Chen, Juan, Yin, Ji-Ye, Li, Xiang-Ping, Wang, Ying, Zheng, Yi, Qian, Chen-Yue, He, Hui, Fang, Chao, Wang, Zhan, Zhang, Yu, Xiao, Ling, Wang, Sai-Ying, Zhang, Wei, Zhou, Hong-Hao, Liu, Zhao-Qian
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Asian Continental Ancestry Group - genetics
Biomarkers, Tumor - genetics
Carcinoma, Non-Small-Cell Lung - drug therapy
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - pathology
Case-Control Studies
CCN Intercellular Signaling Proteins - genetics
Female
Genetic polymorphism
Genetic Predisposition to Disease
Genotype
Hematology, Oncology and Palliative Medicine
Humans
Lung cancer
Lung Neoplasms - drug therapy
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Male
Middle Aged
Platinum Compounds - administration & dosage
Platinum-based chemotherapy
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins - genetics
Pulmonary/Respiratory
Susceptibility
Treatment Outcome
WISP1
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Summary:Micro-Abstract Wnt-inducible signaling pathway protein 1 ( WISP1 ) polymorphisms were associated with multiple lung diseases, including lung cancer. Twenty-eight polymorphisms of WISP1 were selected and genotyped in 556 lung cancer patients and 254 healthy controls. We identified 4 polymorphisms related to lung cancer susceptibility and 5 polymorphisms related to platinum-based chemotherapy response. Genotypes of WISP1 may be used to predict lung cancer susceptibility and chemotherapy response.
ISSN:1525-7304
1938-0690
DOI:10.1016/j.cllc.2014.12.008