Trifolium-like Platinum Nanoparticle-Mediated Photothermal Therapy Inhibits Tumor Growth and Osteolysis in a Bone Metastasis Model

Bone metastasis is a frequent and fatal complication of cancer that lacks effective clinical treatment. Photothermal therapy represents a new strategy for the destruction of multiple cancers. In this study, trifolium‐like platinum nanoparticles (TPNs) with small size and excellent photothermal conve...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2015-05, Vol.11 (17), p.2080-2086
Main Authors: Wang, Changping, Cai, Xiaopan, Zhang, Jishen, Wang, Xinyu, Wang, Yu, Ge, Huyifeng, Yan, Wangjun, Huang, Quan, Xiao, Jianru, Zhang, Qiang, Cheng, Yiyun
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Biocompatible Materials - chemistry
Biomedical materials
Body Weight
bone metastasis
Bone Neoplasms - secondary
Bone Neoplasms - therapy
Bones
Cancer
Cell Line
Cell Line, Tumor
HeLa Cells
Humans
Imaging, Three-Dimensional
Infrared Rays
Metal Nanoparticles - chemistry
Metastasis
Mice
Mice, Nude
Microscopy, Electron, Transmission
Nanoparticles
Nanotechnology
Neoplasm Metastasis
Neoplasms - pathology
NIH 3T3 Cells
osteolysis
Osteolysis - physiopathology
Photochemistry
Phototherapy - methods
photothermal cancer therapy
Platinum
Platinum - chemistry
Platinum Compounds - chemistry
platinum nanoparticles
Povidone - chemistry
Strategy
Therapy
Tomography, X-Ray Computed
Trifolium - chemistry
Tumors
X-Ray Microtomography
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Summary:Bone metastasis is a frequent and fatal complication of cancer that lacks effective clinical treatment. Photothermal therapy represents a new strategy for the destruction of multiple cancers. In this study, trifolium‐like platinum nanoparticles (TPNs) with small size and excellent photothermal conversion property are prepared via a facile and green method. TPNs show minimal cytotoxicity on normal cell lines and kill cancer cells upon exposure to a near‐infrared light. These nanoparticles effectively inhibit tumor growth and prevent osteolysis in a bone metastasis model. This study offers a promising strategy in the treatment of bone metastasis. Photothermal ablation of bone meta­stasis: Trifolium‐like platinum nanoparticle‐mediated photothermal therapy efficiently suppress tumor growth and osteolysis in a bone metastasis model.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201403315