The DNA polymerases of Leishmania mexicana

Two previously isolated DNA polymerases from the parasitic protozoan Leishmania mexicana were further characterized by exposure to inhibitors of mammalian DNA polymerases. DNA polymerase A, a high molecular mass enzyme, and DNA polymerase B, a β‐like DNA polymerase were compared to each other and to...

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Bibliographic Details
Published in:FEMS microbiology letters 1992-08, Vol.95 (1), p.71-75
Main Authors: Nolan, Linda L., Rivera, Jose H.
Format: Article
Language:English
Subjects:
Bacteriology
Biological and medical sciences
Chemotherapy
DNA polymerase
Fundamental and applied biological sciences. Psychology
Leishmania mexicana
Metabolism. Enzymes
Microbiology
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Summary:Two previously isolated DNA polymerases from the parasitic protozoan Leishmania mexicana were further characterized by exposure to inhibitors of mammalian DNA polymerases. DNA polymerase A, a high molecular mass enzyme, and DNA polymerase B, a β‐like DNA polymerase were compared to each other and to their mammalian counterparts regarding pH optimum, utilization of templates, and response to various inhibitors and ionic strengths. The results suggest that the DNA polymerases from L. mexicana differ from the host enzymes and may offer a target for chemotherapeutic intervention.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.1992.tb05344.x